merck millipore,默克密理愽
  • merck millipore,默克密理博,05-443,Anti-VEGF Antibody, clone JH

  • merck millipore,默克密理博,05-443,Anti-VEGF Antibody, clone JH

    产品名称：Anti-VEGF Antibody, clone JH
    产品型号：05-443
    This Anti-VEGF Antibody, clone JH is validated for use in IH(P) for the detection of VEGF.

    merck millipore,默克密理博,05-443,Anti-VEGF Antibody, clone JH

  • 产品介绍
  • merck millipore,默克密理博,05-443,Anti-VEGF Antibody, clone JH

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Rb, H, M, RIH(P)MPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-443
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-VEGF Antibody, clone JH
    Alternate Names
    • vascular endothelial growth factor isoform VEGF165
    • Vascular permeability factor
    • vascular endothelial growth factor
    • vascular endothelial growth factor A
    背景信息 The Flt gene family of receptor tyrosine kinases includes Flt-1, KDR/Flk-1, Flt-3, and Flt-4. They encode receptors for VEGF, characterized by seven Ig-loops within their extracellular domain and a split kinase domain within the cytoplasmic domain. VEGF is an important angiogenic factor of many solid tumors and is also involved in the differentiation of endothelial cells. Flt-1 (Fms-like tyrosine kinase, VEGF-R1) is expressed on endothelial cells and on the common precursors of endothelial and hematopoietic stem cells. KDR (Flk-1, VEGF-R2) is the principal receptor involved in VEGF signaling. KDR is expressed on endothelial cells and stimulates angiogenesis, but is also expressed on bone marrow cells, and is thought to play a role in driving the proliferation of most or all leukemic cells. Flt3 is a class III receptor tyrosine kinase that is closely related to c-Kit and c-Fms. It is expressed in primitive hematopoietic cells and its ligand exerts proliferative effects on these cells in co-operation with other cytokines. Flt3 is also expressed the placenta, testis, spleen, thymus, bone marrow, brain and in cerebellar Purkinje cells. The VEGF receptors stimulate the Ras-MAP kinase pathway, suggesting that it signals as a conventional receptor tyrosine kinase.
    产品信息
    格式 Purified
    控制
    • Expressed in most tissue, including Pancreas, Kidney, Adenocarcinoma.
    演示 Purified mouse monoclonal IgG1k in buffer containing 10 mM PBS, pH 7.4.
    应用
    应用 This Anti-VEGF Antibody, clone JH is validated for use in IH(P) for the detection of VEGF.
    主要应用
    • Immunohistochemistry (Paraffin)
    不建议的应用
    • Western Blotting
    应用说明 Immunohistochemistry: This lot of antibody detected VEGF in formalin fixed, paraffin embedded, human.tissues, using a 1:50 dilution incubated overnight at 4°C.

    Immunoprecipitation: 2 µg of this antibody has been reported to immunoprecipitate VEGF from 1 mg of protein lysate.
    生物信息
    免疫原品种 Recombinant human VEGF121. Clone JH121
    克隆 clone JH
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Recognizes 34-54 kDa isoforms of Vascular Endothelial Growth Factor/Vascular Permeability Factor (VEGF/VPF).
    同种型 IgG1κ
    品种反应性 RabbitHumanMouseRat
    Species Reactivity Note Human, rabbit, mouse, and rat. Other species not tested.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_003376
    Entrez基因汇总 This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms.
    基因符号
    • MGC70609
    • VEGFA
    • VEGF-A
    • VEGF
    • VPF
    纯化方法 Protein G chromatography
    UniProt编号
    • P15692
    UniProt汇总 FUNCTION: SwissProt: P15692 # Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Binds to the VEGFR1/Flt-1 and VEGFR2/Kdr receptors, heparan sulfate and heparin. Neuropilin-1 binds isoforms VEGF-165 and VEGF-145.
    SIZE: 232 amino acids; 27042 Da
    SUBUNIT: Homodimer; disulfide-linked. Also found as heterodimer with PlGF (By similarity).
    SUBCELLULAR LOCATION: Secreted. Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.
    TISSUE SPECIFICITY: The VEGF189, VEGF-165 and VEGF-121 isoforms are widely expressed, whereas the VEGF206 and VEGF-145 are uncommon.
    SIMILARITY: SwissProt: P15692 ## Belongs to the PDGF/VEGF growth factor family.
    产品使用声明
    质量保证 Biological Blockade: Incubation of HUVEC cells with 5 µg/mL of a previous lot and 5 ng/mL of VEGF (Catalog # 01-185) has shown growth inhibition of 20-70%.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,05-443,Anti-VEGF Antibody, clone JH

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