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品种反应性 主要应用 宿主 格式 抗体类型 H WB, ELISA Rb Purified Polyclonal Antibody 描述 产品目录编号 AB3478 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Defensin β3 Antibody Alternate Names - hBD-3
- BD-3
背景信息 Beta Defensin-3 is a novel 5 kDa nonhemolytic antimicrobial protein peptide which may be important in the innate epithelial defense of infections by various microorganisms seen in skin and lung (such as cystic fibrosis). 产品信息 格式 Purified 演示 Purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide. 应用 应用 Anti-Defensin Antibody, β3 is an antibody against Defensin for use in ELISA & WB. 主要应用 - Western Blotting
- ELISA
应用说明 Western blotting: Tricine-SDS- PAGE gels recommended: 1:500-1:1,000, migrates as a 5-6kDa band; Tricine-SDS-urea PAGE gels: Native Beta Defensin 3 migrates as a 9kDa band; the larger size is because of the reduction of the three cysteine bridges present in the peptide protein
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 A synthetic peptide consisting of amino acids 23-33 [GIINTLQKYYC] of the human beta-defensin-3 protein. 宿主 Rabbit 特异性 Recognizes the 5-6 kDa human Defensin-3, beta protein. 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_018661.3
Entrez基因汇总 Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 103B, which has broad spectrum antimicrobial activity and may play an important role in innate epithelial defense. 基因符号 - DEFB-3
- DEFB103A
- HBD3
- HBD-3
- BD-3
- HBP-3
- hBD-3
- BD3
- DEFB103
- DEFB3
- DEFB103B
- HBP3
UniProt编号 - P81534
UniProt汇总 FUNCTION: SwissProt: P81534 # Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistent E.faecium. No significant hemolytic activity was observed.
SIZE: 67 amino acids; 7697 Da
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Highly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. Low expression in salivary gland, bone marrow, colon, stomach, polyp and larynx. No expression in small intestine.
SIMILARITY: SwissProt: P81534 ## Belongs to the beta-defensin family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µg
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