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品种反应性 主要应用 宿主 格式 抗体类型 Rb, H, M WB, ICC M Purified Monoclonal Antibody 描述 产品目录编号 05-384 品牌系列 Upstate
商名 - Upstate
描述 Anti-α-Actinin Antibody, clone AT6/172 产品信息 格式 Purified 控制 - Positive Control Included: Non-Stim A431 Cell Lysate (12-301)
演示 Please see product datasheet for lot-specific formulation. 应用 应用 This Anti-α-Actinin Antibody, clone AT6/172 is validated for use in IC, WB for the detection of α-Actinin. 主要应用 - Western Blotting
- Immunocytochemistry
应用说明 Immunoprecipitation is not recommended 生物信息 免疫原品种 Human α-actinin 克隆 AT6/172 宿主 Mouse 特异性 Recognizes α-actinin. 同种型 IgG1 品种反应性 RabbitHumanMouse 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_001102
Entrez基因汇总 Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. 基因符号 - Alpha-actinin-1
- ACTN1
- FLJ40884
纯化方法 Protein A Purfied UniProt编号 - P12814
UniProt汇总 FUNCTION: SwissProt: P12814 # F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
SIZE: 892 amino acids; 103058 Da
SUBUNIT: Homodimer; antiparallel. Interacts with MYOZ2, PDLIM2 and TTID and LPP.
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z-disk. Note=Colocalizes with MYOZ2 and PPP3CA at the Z-line of heart and skeletal muscle.
SIMILARITY: SwissProt: P12814 ## Belongs to the alpha-actinin family. & Contains 1 actin-binding domain. & Contains 2 CH (calponin-homology) domains. & Contains 2 EF-hand domains. & Contains 4 spectrin repeats.产品使用声明 质量保证 Routinely evaluated in immunoblot on human A431 cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 包装信息 数量 200 µg
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下一件merck millipore产品：merck millipore,默克密理博,SF-1174,HMOX1; Mouse, Cyanine 3 RNA Detection Probe,SmartFlare
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