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品种反应性 主要应用 宿主 格式 抗体类型 R, H, Mk WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABT168 描述 Anti-Girdin Antibody 背景信息 Girdin (Ccdc88a; APE, GIV, or HkRP1) is a ubiquitous protein belonging to the CCDC88 family. Girdin is an actin-binding protein which interacts with actin via its C-terminal domain, and may play a crucial role in cell motility and cytoskeleton remodeling. These effects may be regulated by a reciprocal relationship between Girdin and Akt. Akt phosphorylates Girdin, and Girdin binds to Akt and enhances phosphorylation of Akt, thereby promoting phosphorylation of Akt’s downstream targets such as GSK-3β and FOXO1A. Girdin/Akt signaling may play an important role in cancer by facilitating the proliferation of cancer cells. 产品信息 格式 Affinity Purified 控制 - Cos-7 cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 This Girdin antibody is validated for use in WB, IHC, IF & IP for the detection of the Girdin protein. 主要应用 - Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected Girdin in human colorectal cancer tissues.
Immunofluorescence Analysis: A 1:500 dilution from a representative lot detected Girdin in HeLa, Cos-7, and Att20 cells.
Immunoprecipitation Analysis: A representative lot immunoprecipitated Girdin in HeLa cell lysate.生物信息 免疫原品种 GST-tagged recombinant protein corresponding to the coiled coil domain rat Girdin. 表位 Coiled coil domain. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes the coiled-coil domain of Girdin. 品种反应性 RatHumanMonkey Species Reactivity Note Demonstrated to react with Human and Monkey. Predicted to react with Rat based upon immunogen design. Other homologies: Mouse (97% sequence homology). 抗体类型 Polyclonal Antibody Entrez基因编号 - XP_223709
纯化方法 Affinity purified 产品使用声明 质量保证 Evaluated by Western Blotting in Cos-7 cell lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected Girdin in 10 µg of Cos-7 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,217460,Cardiogenol C - CAS 671225-39-1 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,SF-108,ERalpha; Mouse, Cyanine 5, RNA Detection Probe,SmartFlare
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