merck millipore,默克密理博,04-959,Anti-Retinoid-Related Orphan Receptor γ T Antibody, clone RORg2

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
M	WB	AHm	Purified	Monoclonal Antibody

描述
产品目录编号	04-959
描述	Anti-Retinoid-Related Orphan Receptor γ T Antibody, clone RORg2
Alternate Names	retinoid-related orphan receptor gamma Nuclear receptor RZR-gamma RZR-GAMMA Nuclear receptor subfamily 1 group F member 3 RAR-related orphan receptor C, isoform a Retinoid-related orphan receptor-gamma RAR-related orphan receptor C RAR-related orphan receptor gamma retinoic acid-binding receptor gamma nuclear receptor ROR-gamma
背景信息	Retinoid-related orphan receptor-gamma t (RORγT) is one of two RORγ isoforms belonging to the nuclear hormone receptor family and contains a single nuclear receptor DNA-binding domain. RORγT is a negative regulator of TNFDF6/FASL expression and T-cell production of IL2. The upregulation of RORγT is a requirement for TH17 cell differentiation. Inhibition of RORγT is induced by TGF-β’s interaction with Foxp3. Expression is observed mainly in immature thymocytes, and, during fetal development, is found exclusively in lymphoid-inducer (LTi) cells.

产品信息
格式	Purified
控制	EL4 cell lysate
演示	Purified hamster monoclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

应用
应用	Detect Retinoid-Related Orphan Receptor γ T using this Anti-Retinoid-Related Orphan Receptor γ T Antibody, clone RORg2 validated for use in WB, FC & IF.
主要应用	Western Blotting

生物信息
免疫原品种	Histidine-tagged recombinant protein corresponding to mouse Retinoid-Related Orphan Receptor γ T (RORγT).
表位	Unknown
克隆	RORg2
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Armenian Hamster
品种反应性	Mouse
Species Reactivity Note	Demonstrated to react with mouse.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_035411
基因符号	TOR RORG RZRG NR1F3 RORC
纯化方法	Protein G Purified
UniProt编号	P51450
UniProt汇总	FUNCTION: Orphan nuclear receptor. Isoform 2 negatively regulates expression of TNFSF6/FASL and IL2 production in T-cells. It also binds to the TEA promoter and may participate in the regulation of DNA accessibility in the TCR-Jalpha locus. SUBCELLULAR LOCATION: Nucleus Probable. TISSUE SPECIFICTY: Isoform 1 is widely expressed with highest levels in muscle, kidney and liver. Isoform 2 is expressed primarily in immature thymocytes. Neither isoform is expressed in spleen or bone marrow. SEQUENCE SIMILARITIES: Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain.

产品使用声明
质量保证	Evaluated by Western Blot in EL4 cell lysate. Western Blot Analysis: 2 µg/mL of this antibody detected Retinoid-Related Orphan Receptor γ T (RORγT) in 10 µg of EL4 cell lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	100 µg

merck millipore,默克密理博,04-959,Anti-Retinoid-Related Orphan Receptor γ T Antibody, clone RORg2

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