merck millipore,默克密理愽
  • merck millipore,默克密理博,565792,γ-Secretase Inhibitor XXIII, Aβ42-Selective - Calbiochem

  • merck millipore,默克密理博,565792,γ-Secretase Inhibitor XXIII, Aβ42-Selective - Calbiochem

    产品名称：γ-Secretase Inhibitor XXIII, Aβ42-Selective - Calbiochem
    产品型号：565792
    The γ-Secretase Inhibitor XXIII, Aβ42-Selective controls the biological activity of γ-Secretase.

    merck millipore,默克密理博,565792,γ-Secretase Inhibitor XXIII, Aβ42-Selective - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,565792,γ-Secretase Inhibitor XXIII, Aβ42-Selective - Calbiochem

    重要规格表

    经验配方
    C₃₀H₃₉N₇O
    描述
    概述 A cell-permeable purine compound that acts as a highly potent and selective inhibitor against γ-secretase-mediated production of Aβ42 over Aβ40 (IC50 = 21 and 350 nM, respectively) and Notch1 (Notch IC50/ Aβ42 IC50 >2400) in cultures in vitro. Reported to be blood-brain barrier-permeant and orally bioavailable in APP-YAC transgenic mice and effectively reduce Aβ42 (by 73%), but not Aβ40, level in brain (100 mg/kg, p.o.) in vivo.
    产品目录编号 565792
    品牌系列 Calbiochem®
    参考
    参考 Rivkin, A., et al. 2010. Bioorg. Med. Chem. Lett. 20, 2279.
    产品信息
    形式 Beige solid
    Hill配方 C₃₀H₃₉N₇O
    化学配方 C₃₀H₃₉N₇O
    Molar Mass 513.7
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,565792,γ-Secretase Inhibitor XXIII, Aβ42-Selective - Calbiochem

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