merck millipore,默克密理博,04-217,Anti-phospho-c-Myc (Thr58/Ser62) Antibody, rabbit monoclonal

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merck millipore,默克密理博,04-217,Anti-phospho-c-Myc (Thr58/Ser62) Antibody, rabbit monoclonal
产品名称：Anti-phospho-c-Myc (Thr58/Ser62) Antibody, rabbit monoclonal
产品型号：04-217
Anti-phospho-c-Myc (Thr58/Ser62) Antibody is an antibody against phospho-c-Myc (Thr58/Ser62) for use in IF, IP & WB.

merck millipore,默克密理博,04-217,Anti-phospho-c-Myc (Thr58/Ser62) Antibody, rabbit monoclonal

产品介绍

merck millipore,默克密理博,04-217,Anti-phospho-c-Myc (Thr58/Ser62) Antibody, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
M, H	WB	Rb	Culture Supernatant	Monoclonal Antibody

描述
产品目录编号	04-217
品牌系列	Upstate
商名	Upstate
描述	Anti-phospho-c-Myc (Thr58/Ser62) Antibody, rabbit monoclonal
Alternate Names	v-myc myelocytomatosis viral oncogene homolog (avian) Transcription factor p64 avian myelocytomatosis viral oncogene homolog myc proto-oncogene protein v-myc avian myelocytomatosis viral oncogene homolog
背景信息	Myc is a member of the helix-loop-helix-leucine zipper (bHLH-LZ) family of transcription factors, which dimerizes with Max to activate transcription of some genes and repress others. As Max is essential for Myc activity, the availability of Max is a regulatory mechanism for Myc activity, and members of the Mad family of proteins compete with Myc for Max.

产品信息
格式	Culture Supernatant
控制	Calyculin/Okadaic acid-treted A431 lysate
演示	100 μL of rabbit monoclonal IgG in 60% storage buffer (50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.

应用
应用	Anti-phospho-c-Myc (Thr58/Ser62) Antibody is an antibody against phospho-c-Myc (Thr58/Ser62) for use in IF, IP & WB.
主要应用	Western Blotting
应用说明	Suggested dilutions: Western Blot: 1:10,000 Immunocytochemistry: 1:50-1:100 Immunoprecipitation: 1:100

生物信息
免疫原品种	Synthetic peptide corresponding to sequence surrounding and including phosphorylated Thr58 and Ser62 of human c-Myc.
表位	phosphorylated Thr58/Ser62
宿主	Rabbit
特异性	c-Myc when phosphorylated on residues Thr58/Ser62.
同种型	IgG
品种反应性	MouseHuman
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_002458.2
Entrez基因汇总	The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
基因符号	C-MYC c-Myc C-Myc MYC
修改	Phosphorylation
非反应性品种	Rat
纯化方法	Unpurified
UniProt编号	P01106
UniProt汇总	FUNCTION: SwissProt: P01106 # Participates in the regulation of gene transcription. Binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes. SIZE: 439 amino acids; 48804 Da SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with JARID1A and JARID1B. SUBCELLULAR LOCATION: Nucleus. PTM: Phosphorylated by PRKDC. DISEASE: SwissProt: P01106 # Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors. & A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1. SIMILARITY: SwissProt: P01106 ## Contains 1 basic helix-loop-helix (bHLH) domain.

产品使用声明
质量保证	Routinely evaluated by immunoblot.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20ºC from date of receipt.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.