merck millipore,默克密理愽
  • merck millipore,默克密理博,04-803,Anti-HMGN2/HMG17 Antibody, clone 10D6.3

  • merck millipore,默克密理博,04-803,Anti-HMGN2/HMG17 Antibody, clone 10D6.3

    产品名称：Anti-HMGN2/HMG17 Antibody, clone 10D6.3
    产品型号：04-803
    This Anti-HMGN2/HMG17 Antibody, clone 10D6.3 is validated for use in WB, IF for the detection of HMGN2/HMG17.

    merck millipore,默克密理博,04-803,Anti-HMGN2/HMG17 Antibody, clone 10D6.3

  • 产品介绍
  • merck millipore,默克密理博,04-803,Anti-HMGN2/HMG17 Antibody, clone 10D6.3

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 04-803
    描述 Anti-HMGN2/HMG17 Antibody, clone 10D6.3
    Alternate Names
    • nonhistone chromosomal protein HMG-17
    • High-mobility group nucleosome-binding domain-containing protein 2
    • high mobility group protein N2
    • high-mobility group (nonhistone chromosomal) protein 17
    • high-mobility group nucleosomal binding domain 2
    背景信息 HMGN2 (High Mobility Group Nucleosomal binding domain 2), also known as HMG17, is an abundant, nonhistone chromosomal protein that binds preferentially to nucleosomal core particles of mammalian chromatin. HMGN2 binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. It acts as a chromatin-specific transcriptional coactivator that increases the efficiency of initiation of transcription by RNA polymerase II. HMGN2 also plays a role in chromatin assembly and conformation.
    产品信息
    格式 Purified
    控制
    • HL60 cell lysates
    演示 Purified from ascites by protein G chromatography. Supplied at 1 mg/mL in 0.1M Tris-Glycine (pH7.4), 150mM NaCl, 0.05% NaN3.
    应用
    应用 This Anti-HMGN2/HMG17 Antibody, clone 10D6.3 is validated for use in WB, IF for the detection of HMGN2/HMG17.
    主要应用
    • Western Blotting
    应用说明 Western Blot Analysis:
    A 0.1 μg/mL dilution of this lot detected HMGN2/HMG17 in HL60 cell lysates.
    Immunofluorescence:
    The antibody detected HMGN2/HMG17 in NIH/3T3 and A431 cells.
    生物信息
    免疫原品种 The immunogen used was a GST fusion protein of whole recombinant HMGN2.
    克隆 10D6.3
    宿主 Mouse
    特异性 Recognizes HMGN2/HMG17, Mr 9.3 kDa (calculated). Appears at 11-18 kDa by polyacrylamide gel electrophoresis.
    同种型 IgG2aκ
    品种反应性 RatHumanMouse
    Species Reactivity Note Human, mouse, rat. Cross-reactivity not tested on other species.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_005517.3
    基因符号
    • MGC88718
    • HMG17
    • MGC5629
    纯化方法 Purified
    UniProt编号
    • P05204
    UniProt汇总 FUNCTION: Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in an unique chromatin conformation (By similarity).
    INTERACTION:
    P62993:GRB2; NbExp=1; IntAct=EBI-1758689, EBI-401755;
    SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Cytoplasmic enrichment upon phosphorylation.
    PTM: Phosphorylation favors cytoplasmic localization.
    MASS SPECTROMETRY: Mass=9261.5; Method=Electrospray; Range=2-90; Source=PubMed:10739259;.
    MASS SPECTROMETRY: Mass=9341.3; Mass_error=1.9; Method=Electrospray; Range=2-90; Source=PubMed:10739259;.
    MASS SPECTROMETRY: Mass=9421.5; Method=Electrospray; Range=2-90; Source=PubMed:10739259;.
    SIMILARITY: Belongs to the HMGN family.
    产品使用声明
    质量保证 Routinely evaluated by western blot analysis.

    Western Blot Analysis:
    A 0.1 μg/mL dilution of this lot detected HMGN2/HMG17 in HL60 cell lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt. For maximum recovery of product, centrifuge the vial prior to removing the cap.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,04-803,Anti-HMGN2/HMG17 Antibody, clone 10D6.3

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下一件merck millipore产品：merck millipore,默克密理博,17851,Aquacide II


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