merck millipore,默克密理博,04-430,Anti-AIF Antibody, rabbit monoclonal

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merck millipore,默克密理博,04-430,Anti-AIF Antibody, rabbit monoclonal
产品名称：Anti-AIF Antibody, rabbit monoclonal
产品型号：04-430
Detect AIF using this Anti-AIF Antibody, Rabbit validated for use in FC, IF, IP, WB, IH(P).

merck millipore,默克密理博,04-430,Anti-AIF Antibody, rabbit monoclonal

产品介绍

merck millipore,默克密理博,04-430,Anti-AIF Antibody, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
R, H, M	WB, FC	Rb	Purified	Monoclonal Antibody

描述
产品目录编号	04-430
品牌系列	Upstate
商名	Upstate
描述	Anti-AIF Antibody, rabbit monoclonal

产品信息
格式	Purified
演示	In 60% storage buffer (50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.

应用
应用	Detect AIF using this Anti-AIF Antibody, Rabbit validated for use in FC, IF, IP, WB, IH(P).
主要应用	Western Blotting Flow Cytometry

生物信息
免疫原品种	KLH-conjugated synthetic peptide corresponding to the C-terminal region of human AIF.
宿主	Rabbit
特异性	Recognizes a region near the C-terminus domain of human AIF.
同种型	IgG
品种反应性	RatHumanMouse
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_145813.1 NM_004208.2 NM_145812.1
Entrez基因汇总	This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it effects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Three alternative transcripts encoding different isoforms have been identified for this gene.
基因符号	PDCD8 AIFM1 AIF MGC111425
UniProt编号	O95831
UniProt汇总	FUNCTION: SwissProt: O95831 # Probable oxidoreductase that acts as a caspase- independent mitochondrial effector of apoptotic cell death. Extramitochondrial AIF induces nuclear chromatin condensation and large scale DNA fragmentation (in vitro). COFACTOR: FAD. SIZE: 613 amino acids; 66901 Da SUBUNIT: Binds to DNA in a sequence-independent manner. SUBCELLULAR LOCATION: Mitochondrion intermembrane space. Nucleus. Note=Translocated to the nucleus upon induction of apoptosis. SIMILARITY: SwissProt: O95831 ## Belongs to the FAD-dependent oxidoreductase family.

产品使用声明
质量保证	Routinely evaluated by immunoblot.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	2 year at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.

储存和货运信息

存储条件

2 year at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.