merck millipore,默克密理愽
  • merck millipore,默克密理博,04-293,Anti-phospho-erbB2 (Thr686) Antibody, clone 7F8

  • merck millipore,默克密理博,04-293,Anti-phospho-erbB2 (Thr686) Antibody, clone 7F8

    产品名称：Anti-phospho-erbB2 (Thr686) Antibody, clone 7F8
    产品型号：04-293
    Anti-phospho-erbB2 (Thr686) Antibody, clone 7F8 is an antibody against phospho-erbB2 (Thr686) for use in ELISA & WB.

    merck millipore,默克密理博,04-293,Anti-phospho-erbB2 (Thr686) Antibody, clone 7F8

  • 产品介绍
  • merck millipore,默克密理博,04-293,Anti-phospho-erbB2 (Thr686) Antibody, clone 7F8

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, Ca, HWB, ELISAMPurifiedMonoclonal Antibody
    描述
    产品目录编号 04-293
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-erbB2 (Thr686) Antibody, clone 7F8
    Alternate Names
    • NEU
    • NGL
    • HER2
    • TKR1
    • HER-2
    • c-erb B2
    产品信息
    格式 Purified
    控制
    • Includes EGF treated A431 cell lysates as positive control
    演示 In 1 mL of PBS containing 0.09% sodium azide, PEG, sucrose and 50% glycerol.
    应用
    应用 Anti-phospho-erbB2 (Thr686) Antibody, clone 7F8 is an antibody against phospho-erbB2 (Thr686) for use in ELISA & WB.
    主要应用
    • Western Blotting
    • ELISA
    生物信息
    免疫原品种 KLH-conjugated synthetic peptide encompassing the surrounding amino acids of Thr 686 in human erbB2
    克隆 7F8
    宿主 Mouse
    特异性 Recognizes phosphorylated erbB2 on Threonine 686
    同种型 IgG1
    品种反应性 MouseCanineHuman
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_004448.2
    • NM_001005862.1
    Entrez基因汇总 This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
    基因符号
    • HER-2/neu
    • ERBB2
    • HER2
    • HER-2
    • NGL
    • herstatin
    • erbB-2
    • C-erbB-2
    • NEU
    • TKR1
    • p185erbB2
    修改
    • Phosphorylation
    纯化方法 Subsequent thiophilic adsorption and size exclusion chromatography
    UniProt编号
    • P04626
    UniProt汇总 FUNCTION: SwissProt: P04626 # Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF- alpha and amphiregulin.
    SIZE: 1255 amino acids; 137910 Da
    SUBUNIT: Heterodimer with each of the other ERBB receptors (Potential). Interacts with PRKCABP and PLXNB1. Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196. Interacts with MEMO when phosphorylated on Tyr-1248.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    PTM: Ligand-binding increases phosphorylation on tyrosine residues (By similarity).
    SIMILARITY: SwissProt: P04626 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 Routinely evaluated by immunoblot.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C from date of shipment. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,04-293,Anti-phospho-erbB2 (Thr686) Antibody, clone 7F8

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