merck millipore,默克密理愽
  • merck millipore,默克密理博,04-1551,Anti-SMRT Antibody, clone 1SM-1E7

  • merck millipore,默克密理博,04-1551,Anti-SMRT Antibody, clone 1SM-1E7

    产品名称：Anti-SMRT Antibody, clone 1SM-1E7
    产品型号：04-1551
    Use Anti-SMRT Antibody, clone 1SM-1E7 (Mouse Monoclonal Antibody) validated in WB to detect SMRT also known as CTG repeat protein 26, Silencing mediator of retinoic acid & thyroid hormone receptor.

    merck millipore,默克密理博,04-1551,Anti-SMRT Antibody, clone 1SM-1E7

  • 产品介绍
  • merck millipore,默克密理博,04-1551,Anti-SMRT Antibody, clone 1SM-1E7

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWBMAscitesMonoclonal Antibody
    描述
    产品目录编号 04-1551
    描述 Anti-SMRT Antibody, clone 1SM-1E7
    Alternate Names
    • silencing mediator for retinoid and thyroid hormone receptors
    • CTG repeat protein 26
    • Silencing mediator of retinoic acid and thyroid hormone receptor
    • T3 receptor-associating factor
    • Thyroid-, retinoic-acid-receptor-associated corepressor
    • nuclear receptor co-repressor 2
    背景信息 The Silencing mediator of retinoic acid & thyroid hormone receptor protein, commonly called the SMRT protein mediates the transcriptional repression of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription machinery. Consistent with this activity, this protein is known to form a large corepressor complex containing SIN3A/B and histone deacetylases HDAC1 and HDAC2. SMRT is also a component of the N-Cor repressor (nuclear receptor corepressor), a multi-subunit complex minimally composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. SMRT and nuclear receptor corepressor N-CoR are related transcriptional corepressors which contain two distinct domains capable of interacting with unliganded nuclear receptors to repress their basal transcriptional activity.
    产品信息
    格式 Ascites
    控制
    • Human brain lysate
    演示 Unpurified mouse monoclonal IgG2aκ ascites with 0.05% sodium azide.
    应用
    应用 Use Anti-SMRT Antibody, clone 1SM-1E7 (Mouse Monoclonal Antibody) validated in WB to detect SMRT also known as CTG repeat protein 26, Silencing mediator of retinoic acid & thyroid hormone receptor.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 Recombinant protein corresponding to human SMRT.
    表位 Unknown
    克隆 1SM-1E7
    宿主 Mouse
    特异性 This antibody recognizes SMRT.
    同种型 IgG2aκ
    品种反应性 RatHumanMouse
    Species Reactivity Note Demonstrated to react with human, mouse, and rat.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001070729.1
    基因符号
    • TRAC1
    • NCOR2
    • CTG26
    • N-CoR2
    • SMAP270
    • SMRT
    • SMRTE
    • SMRTE-tau
    • TNRC14
    • TRAC
    • TRAC-1
    纯化方法 Unpurified
    UniProt编号
    • Q9Y618
    UniProt汇总 FUNCTION: Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription.

    SIZE: 2517 amino acids; 274034 Da

    SUBUNIT: Interacts with HDAC7 (By similarity). Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. The SRMT isoform interacts with HDAC10. Interacts with MINT. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with CBFA2T3.

    SUBCELLULAR LOCATION: Nucleus.

    TISSUE SPECIFICITY: Ubiquitous. High levels of expression are detected in lung, spleen and brain.

    DOMAIN: SwissProt: Q9Y618 The N-terminal region contains repression functions that are divided into three independent repression domains (RD1, RD2 and RD3). The C-terminal region contains the nuclear receptor- interacting domains that are divided in two separate interaction domains (ID1 and ID2). & The two interaction domains (ID) contain a conserved sequence referred to as the CORNR box. This motif is required and sufficient to permit binding to unligated TR and RARS. Sequences flanking the CORNR box determine nuclear hormone receptor specificity.

    SIMILARITY: Belongs to the N-CoR nuclear receptor corepressors family. & Contains 2 SANT domains.
    产品使用声明
    质量保证 Evaluated by Western Blot in human brain lysate.

    Western Blot Analysis: 1:1,000 dilution of this antibody detected SMRT on 10 µg of human brain lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20°C from date of receipt.
    Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,04-1551,Anti-SMRT Antibody, clone 1SM-1E7

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