merck millipore,默克密理愽
  • merck millipore,默克密理博,04-1506,Anti-CTCF Antibody, clone 1.2.1.5.4

  • merck millipore,默克密理博,04-1506,Anti-CTCF Antibody, clone 1.2.1.5.4

    产品名称：Anti-CTCF Antibody, clone 1.2.1.5.4
    产品型号：04-1506
    Anti-CTCF Antibody, clone 1.2.1.5.4 is a Mouse Monoclonal Antibody for detection of CTCF also known as 11-zinc finger protein, CCCTC-binding factor & has been validated in WB, IP & IHC.

    merck millipore,默克密理博,04-1506,Anti-CTCF Antibody, clone 1.2.1.5.4

  • 产品介绍
  • merck millipore,默克密理博,04-1506,Anti-CTCF Antibody, clone 1.2.1.5.4

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HChIP, WB, IHCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 04-1506
    Replaces MABE547
    描述 Anti-CTCF Antibody, clone 1.2.1.5.4
    Alternate Names
    • transcriptional repressor CTCF
    • 11 zinc finger transcriptional repressor
    • 11-zinc finger protein
    • CCCTC-binding factor
    • CCCTC-binding factor (zinc finger protein)
    • CTCFL paralog
    背景信息 CTCF, also known as CCCTC-binding factor, contains 11 zinc finger (ZF) binding domains that allow it to bind different DNA target sequences and proteins. This multifunctional protein can act as a transcriptional activator or repressor. As a transcriptional repressor, CTCF, binds to promoters of vertebrate c-myc gene. It also binds to the PLK and PIM1 promoters. CTCF may prevent the access of transcriptional activators to enhancers. CTCF also acts as a transcriptional activator of APP. It is involved in different aspects of gene regulation including promoter activation or repression, hormone-responsive gene silencing, methylation-dependent chromatin insulation, and genomic imprinting. Mutations of CTCF in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms tumors, suggesting a role for CTCF may as a tumor suppressor.
    产品信息
    格式 Purified
    控制
    • K562 cell lysate
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
    应用
    应用 Anti-CTCF Antibody, clone 1.2.1.5.4 is a Mouse Monoclonal Antibody for detection of CTCF also known as 11-zinc finger protein, CCCTC-binding factor & has been validated in WB, IP & IHC.
    主要应用
    • Chromatin Immunoprecipitation (ChIP)
    • Western Blotting
    • Immunohistochemistry
    应用说明 Chromatin Immunoprecipitation Analysis:
    A representative lot was used by an independent laboratory in ChIP. (Pugacheva, E., et al. (2005). Human Molecular Genetics. 14(7):953–965.)
    生物信息
    免疫原品种 His-tagged recombinant protein corresponding to human CTCF.
    表位 Unknown
    克隆 1.2.1.5.4
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody recognizes CTCF.
    同种型 IgG1κ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_006556.1
    Entrez基因汇总 This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. [provided by RefSeq].
    基因符号
    • CTCF
    纯化方法 Protein G purfied
    UniProt编号
    • P49711
    UniProt汇总 FUNCTION: Transcriptional repressor binding to promoters of vertebrate c-myc gene. Also binds to the PLK and PIM1 promoters. May prevent the access of transcriptional activators to enhancers. Also acts as a transcriptional activator of APP. Involved in different aspects of gene regulation including promoter activation or repression, hormone-responsive gene silencing, methylation- dependent chromatin insulation, and genomic imprinting. Seems to act as tumor suppressor.r/>SIZE: 727 amino acids; 82785 Da

    SUBCELLULAR LOCATION: Nucleus.

    TISSUE SPECIFICITY:Ubiquitous. Absent in primary spermatocytes.

    SIMILARITY: Belongs to the CTCF zinc-finger protein family. & Contains 11 C2H2-type zinc fingers.
    产品使用声明
    质量保证 Evaluated by Western Blot in K562 cell lysate.

    Western Blot Analysis: 1 µg/ml of this antibody detected CTCF on 10 µg of K562 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,04-1506,Anti-CTCF Antibody, clone 1.2.1.5.4

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