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品种反应性 主要应用 宿主 格式 抗体类型 M WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB5727 Replaces AB5774 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Sox10 Antibody 背景信息 Sox 10 is part of a family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Sox 10 is expressed in multipotent neural crest stem cells, and its expression is downregulated upon their differentiation. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease. 产品信息 格式 Affinity Purified 演示 Affinity purified immunoglobulin. Liquid. 应用 应用 Anti-Sox10 Antibody detects level of Sox10 & has been published & validated for use in WB. 主要应用 - Western Blotting
应用说明 Western blot: 0.1-0.5 μg/mL using ECL on fetal mouse brain tissue lysate. The antibody reacts with proteins of ~60 kDa. An additional band of ~120 kDa may also be seen depending on sample used.
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Synthetic peptide from Sox10. 宿主 Rabbit 特异性 Sox10. The immunogen sequence is 70% conserved with Sox8 and Sox9 and therefore the antibody may show cross reactivity to these proteins. 品种反应性 Mouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_006941.3
Entrez基因汇总 This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease. 基因符号 - MGC15649
- SOX10
- OTTHUMP00000028515
- WS4
- DOM
- WS2E
UniProt编号 - P56693
UniProt汇总 FUNCTION: SwissProt: P56693 # Transcription factor that seems to function synergistically with the POU domain protein TST-1/OCT6/SCIP. Could confer cell specificity to the function of other transcription factors in developing and mature glia (By similarity).
SIZE: 466 amino acids; 49911 Da
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
TISSUE SPECIFICITY: Expressed in fetal brain and in adult brain, heart, small intestine and colon.
DISEASE: SwissProt: P56693 # Defects in SOX10 are a cause of Waardenburg syndrome type IV (WS4) [MIM:277580]; also known as Waardenburg-Shah syndrome. WS4 is characterized by the association of Waardenburg features (depigmentation and deafness) and the absence of enteric ganglia in the distal part of the intestine (Hirschsprung disease). & Defects in SOX10 are a cause of Yemenite deaf-blind hypopigmentation syndrome [MIM:601706]. The disorder consists of cutaneous hypopigmented and hyperpigmented spots and patches, microcornea, coloboma and severe hearing loss. Another case observed in a girl with similar skin symptoms and hearing loss but without microcornea or coloboma is reported as a mild form of this syndrome. & Defects in SOX10 are the cause of peripheral demyelinating neuropathy, central dysmyelinating leukodystrophy, Waardenburg syndrome, and Hirschsprung disease (PCWH) [MIM:609136]; also called neurologic variant of Waardenburg-Shah syndrome. PCWH is a rare, complex and more severe neurocristopathy that includes features of 4 distinct syndromes: peripheral demyelinating neuropathy, central dysmyelinating leukodystrophy, Waardenburg syndrome, and Hirschsprung disease.
SIMILARITY: SwissProt: P56693 ## Contains 1 HMG box DNA-binding domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at +2-8°C in undiluted aliquots for up to 6 months after date of receipt. 包装信息 数量 100 µg
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