merck millipore,默克密理博,16-209,Anti-GST Tag Antibody, clone DG122-2A7, HRP conjugate

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merck millipore,默克密理博,16-209,Anti-GST Tag Antibody, clone DG122-2A7, HRP conjugate
产品名称：Anti-GST Tag Antibody, clone DG122-2A7, HRP conjugate
产品型号：16-209
Anti-GST Tag Antibody, clone DG122-2A7, HRP conjugate detects level of GST Tag & has been published & validated for use in WB.

merck millipore,默克密理博,16-209,Anti-GST Tag Antibody, clone DG122-2A7, HRP conjugate

产品介绍

merck millipore,默克密理博,16-209,Anti-GST Tag Antibody, clone DG122-2A7, HRP conjugate

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
Schistosoma japonicum	WB	M	HRP	Monoclonal Antibody

描述
产品目录编号	16-209
品牌系列	Upstate
商名	Upstate
描述	Anti-GST Tag Antibody, clone DG122-2A7, HRP conjugate
概述	Immunogen: GST (Glutathione S-transferase) derived from the pGEX expression vector and linked to KLH. Specificity: Recognizes GST-fusion proteins.
Alternate Names	zeta-chain associated protein kinase, 70kD 70 kDa zeta-associated protein Syk-related tyrosine kinase zeta-chain (TCR) associated protein kinase (70 kD) zeta-chain (TCR) associated protein kinase 70kDa zeta-chain associated protein kinase 70kDa zeta-chain associated protein kinase
背景信息	Glutathione S transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunological, and structural properties, the soluble human GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. The amino acid sequence GST is highly conserved in most organisms, including mammals.

产品信息
格式	HRP
控制	Cells expressing the GST-tag.
演示	Purified mouse monoclonal IgG in buffer containing (HRP) in 70% storage buffer PBS with 0.05% Kathon® and 30% glycerol. Liquid at -20°C.

应用
应用	Anti-GST Tag Antibody, clone DG122-2A7, HRP conjugate detects level of GST Tag & has been published & validated for use in WB.
主要应用	Western Blotting

生物信息
免疫原品种	GST (Glutathione S-transferase) derived from the pGEX expression vector and linked to KLH. Clone DG122-2A7.
表位	N/A
克隆	DG122-2A7
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Mouse
特异性	Recognizes GST-fusion proteins.
同种型	IgG
品种反应性	Schistosoma japonicum
Species Reactivity Note	Schistosoma japonicum
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_001070
Entrez基因汇总	This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
基因符号	SRK ZAP70 ZAP-70 TZK STD
纯化方法	Protein G purfied
UniProt编号	P43403
UniProt汇总	FUNCTION: SwissProt: P43403 # Associates with the T-cell antigen receptor zeta chain (CD3Z). Plays a role in lymphocyte activation. SIZE: 619 amino acids; 69872 Da SUBUNIT: Interacts with SLA2 when it is phosphorylated. Interacts with CD3Z and with phosphorylated NFAM1. Interacts with CBLB (By similarity). Interacts with CBL and SLA when it is phosphorylated. The association with SLA (or SLA2) and CBL probably leads to its destruction. Interacts with SHB. Interacts with DEF6 (By similarity). TISSUE SPECIFICITY: Expressed in T- and natural killer cells. DOMAIN: SwissProt: P43403 The SH2 domain binds to the phosphorylated tyrosine-based activation motif (TAM) of CD3Z. PTM: Phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation. Tyr-319 phosphorylation is essential for full activity. DISEASE:SwissProt: P43403 # Defects in ZAP70 are the cause of selective T-cell defect (STD) [MIM:176947]. STD is an autosomal recessive form of severe combined immunodeficiency characterized by a selective absence of CD8-type T-cells. SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily. & Contains 1 protein kinase domain. & Contains 2 SH2 domains

产品使用声明
质量保证	Routinely evaluated by western blot Analysis on recombinant GST protein. Western Blot Analysis: 1:500-1:1000 dilution of this lot detected recombinant GST protein.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variabillity in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variabillity in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.