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merck millipore,默克密理博,SF-798,TIMP2; Human, Cyanine 3, RNA Detection Probe,SmartFlare
产品名称：TIMP2; Human, Cyanine 3, RNA Detection Probe, SmartFlare
产品型号：SF-798
Use SmartFlare RNA Detection probes to measure gene expression in live cells. With an overnight incubation of SmartFlare TIMP2, Human, Cyanine 3, you can detect TIMP2 RNA levels within your cells.
merck millipore,默克密理博,SF-798,TIMP2; Human, Cyanine 3, RNA Detection Probe,SmartFlare
- 产品介绍
重要规格表
Entrez Gene Number Species Reactivity NM_003255.4 H 描述 产品目录编号 SF-798 商名 - SmartFlare
描述 TIMP2; Human, Cyanine 3, RNA Detection Probe | SmartFlare Alternate Names - CSC-21K
背景信息 With SmartFlare™ RNA Detection probes, you can detect RNA in LIVE CELLS with ease. With just an overnight incubation of TIMP2; Human, Cyanine 3, RNA Detection Probe you can detect the presence of TIMP2 within your cells.
Matrix metalloproteinases (MMPs) are a family of enzymes that are responsible for the degradation of extracellular matrix components such as collagen, laminin and proteoglycans. In addition to sequence homology, all MMPs share the following characteristics: the catalytic mechanism is dependent upon a zinc ion at the active center, they cleave one or more extracellular matrix components, they are secreted as zymogens which are activated by removal of an ~10 kDa segment from the N-terminus and they are inhibited by tissue inhibitor of metalloproteinases (TIMP). These enzymes are involved in normal physiological processes such as embryogenesis and tissue remodeling and may play an important role in angiogenesis, arthritis, periodontitis, and metastasis.
A family of endogenous inhibitors, tissue inhibitors of metalloproteinase (TIMP), regulate the activation and activity of MMPs. TIMPs are capable of altering the metastatic potential of cancer cells and have been shown to inhibit invasion and metastasis in animal models. TIMP-2 is a 194 amino acid unglycosylated protein of 21 kDa with 43% and 44% sequence homology to TIMP-1 and TIMP-3, respectively. TIMP-2 inhibits the activity of all active MMPs and regulates the activation of pro-MMP-2 by binding to the C-terminal region of pro-MMP-2 (Kd ~5 nM). As with TIMP-1, TIMP-2 has been shown to have erythroid potentiating activity and cell growth-promoting activity.产品信息 格式 Cyanine 3 演示 Lyophilized 应用 应用 Use SmartFlare RNA Detection probes to measure gene expression in live cells. With an overnight incubation of SmartFlare TIMP2, Human, Cyanine 3, you can detect TIMP2 RNA levels within your cells. 主要应用 - RNA Detection
生物信息 品种反应性 Human Entrez基因编号 - NM_003255.4
基因符号 - TIMP2
产品使用声明 质量保证 SmartFlare Probes have been tested in a buffer system to detect the release of the fluorophore in the presence of a complimentary base pair sequence for each lot to confirm target specificity. SmartFlare Probes have also been tested in a cell model system and demonstrated increased fluorescence in cells expressing the target compared to a negative SmartFlare Scramble Control. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Store at 2–8°C in lyophilized format ONLY. Room temperature is required for reconstituted product. 包装信息 数量 250 reactions
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