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merck millipore,默克密理博,521231,PDGFR Tyrosine Kinase Inhibitor II - CAS 249762-74-1 - Calbiochem
产品名称：PDGFR Tyrosine Kinase Inhibitor II - CAS 249762-74-1 - Calbiochem
产品型号：521231
The PDGFR Tyrosine Kinase Inhibitor II, also referenced under CAS 249762-74-1, controls the biological activity of PDGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphoryl More>>
merck millipore,默克密理博,521231,PDGFR Tyrosine Kinase Inhibitor II - CAS 249762-74-1 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₁H₁₈N₂O₃ 249762-74-1 描述 概述 A cell-permeable bis(1H-2-indolyl)-1-methanone compound that acts as a highly selective, ATP-competitive and reversible inhibitor of platelet-derived growth factor (PDGF) receptor tyrosine kinase (IC50 = 1.1 µM in Swiss 3T3 cells for PDGFR). Also potently inhibits Flt3 (Fms-like tyrosine kinase 3) activity (IC50 = 6.2 µM for hPDGFβ-R-mFlt3 and 50 nM in EOL-1 cells). Sensitizes 32D cells to radiation-induced apoptosis and inhibits proliferation of TEL-Flt3-transfected BA/F3 cells (IC50 < 300 nM). May also serve as a prodrug form of the Platelet Derived Growth Factor Receptor Tyrosine Kinase Inhibitor I (Cat. No. 521230) in cells. 产品目录编号 521231 品牌系列 Calbiochem®
同义词 (5-Butanoate-1H-2-indolyl)(1H-2-indolyl)-methanone, [2-(1H-2-Indolylcarbonyl)-1H-5-indolyl]butanoate, D-65476 参考 参考 Mahboobi, S., et al. 2002. J. Med. Chem. 45, 1002.
Teller, S., et al. 2002. Leukemia 16, 1528.产品信息 CAS号 249762-74-1 具有ATP竞争性 Y 形式 Yellow solid Hill配方 C₂₁H₁₈N₂O₃ 化学配方 C₂₁H₁₈N₂O₃ Molar Mass 346.4 可逆 Y 结构配方图像 生物信息 主靶 PDGFR in swiss 3T3 cells 主靶IC50 1.1 µM inhibiting PDGFR in swiss 3T3 cells; 6.2 µ M for hPDGFβ-R-mFlt3 and 50 nM in EOL-1 cells 纯度 ≥97% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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