merck millipore,默克密理愽
  • merck millipore,默克密理博,203980,α-Bungarotoxin, Bungarus multicinctus - CAS 11032-79-4 - Calbiochem

  • merck millipore,默克密理博,203980,α-Bungarotoxin, Bungarus multicinctus - CAS 11032-79-4 - Calbiochem

    产品名称：α-Bungarotoxin, Bungarus multicinctus - CAS 11032-79-4 - Calbiochem
    产品型号：203980
    Blocks neuromuscular transmission by irreversible binding to motor end-plate acetylcholine receptor (Kd = 1 pM to 1 nM) but does not depress acetylcholine release from motor nerve endings.

    merck millipore,默克密理博,203980,α-Bungarotoxin, Bungarus multicinctus - CAS 11032-79-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,203980,α-Bungarotoxin, Bungarus multicinctus - CAS 11032-79-4 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₃₃₈H₅₂₉N₉₇O₁₀₅S₁₁11032-79-4
    描述
    概述 Blocks neuromuscular transmission by irreversible binding to motor end-plate acetylcholine receptor (Kd = 1 pM to 1 nM) but does not depress acetylcholine release from motor nerve endings. Blocks nicotine-induced increase of intracellular Ca2+ in PC12 cells (IC50 = 310 nM), and prevents opening of nicotinic receptor-associated ion channels. Reconstitution experiments in Xenopus oocytes have shown the effects of α-bungarotoxin on neuronal nAChR to be highly specific for the α7-subtype (IC50 = 1.6 nM), but not for the α3β4-subtype (IC50 >3 µM).
    产品目录编号 203980
    品牌系列 Calbiochem®
    参考
    参考 Lopez, M.G., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14184.
    Zhang, Z.W., et al. 1994. Neuron 12, 167.
    Bambrick, L.L., and Gordon, T. 1992. J. Physiol. 449, 479.
    Lin, S.R., and Chang, C.C. 1992. Biochim. Biophys. Acta 1159, 255.
    Motomura, M., et al. 1992. Neurosci. Lett. 143, 139.
    Sorenson, E.M., and Chiappinelli, V.A. 1992. J. Comp. Neurol. 323, 1.
    Ruan, K.H., et al. 1990. 87, 6156.
    产品信息
    CAS号 11032-79-4
    具有ATP竞争性 N
    形式 Lyophilized solid
    Hill配方 C₃₃₈H₅₂₉N₉₇O₁₀₅S₁₁
    化学配方 C₃₃₈H₅₂₉N₉₇O₁₀₅S₁₁
    Molar Mass 7984.3
    肽序列 H-Ile-Val-Cys³-His-Thr-Thr-Ala-Thr-Ser-Pro-Ile-Ser-Ala-Val-Thr-Cys¹⁶-Pro-Pro-Gly-Glu-Asn-Leu-Cys²³-Tyr-Arg-Lys-Met-Trp-Cys²⁹-Asp-Ala-Phe-Cys³³-Ser-Ser-Arg-Gly-Lys-Val-Val-Glu-Leu-Gly-Cys⁴⁴-Ala-Ala-Thr-Cys⁴⁸-Pro-Ser-Lys-Lys-Pro-Tyr-Glu-Glu-Val-Thr-Cys⁵⁹-Cys⁶⁰-Ser-Thr-Asp-Lys-Cys⁶⁵-Asn-Pro-His-Pro-Lys-Gln-Arg-Pro-Gly-OH (disulfide bonds: 3 → 23; 16 → 44; 29 → 33; 48 → 59; 60 → 65)
    可逆 N
    生物信息
    主靶 Motor end-plate acetylcholine receptor
    主靶IC50 Kd = 1 pM to 1 nM for motor end-plate acetylcholine receptor
    理化信息
    细胞可渗透 N
    污染物 None detectable by IEF. Supplied as an acetate salt
    溶解度 H₂O or PBS
    肽序列 H-Ile-Val-Cys³-His-Thr-Thr-Ala-Thr-Ser-Pro-Ile-Ser-Ala-Val-Thr-Cys¹⁶-Pro-Pro-Gly-Glu-Asn-Leu-Cys²³-Tyr-Arg-Lys-Met-Trp-Cys²⁹-Asp-Ala-Phe-Cys³³-Ser-Ser-Arg-Gly-Lys-Val-Val-Glu-Leu-Gly-Cys⁴⁴-Ala-Ala-Thr-Cys⁴⁸-Pro-Ser-Lys-Lys-Pro-Tyr-Glu-Glu-Val-Thr-Cys⁵⁹-Cys⁶⁰-Ser-Thr-Asp-Lys-Cys⁶⁵-Asn-Pro-His-Pro-Lys-Gln-Arg-Pro-Gly-OH (disulfide bonds: 3 → 23; 16 → 44; 29 → 33; 48 → 59; 60 → 65)
    GHS安全信息
    RTECS EI6201400
    安全信息
    R相 R: 20/21/22

    Harmful by inhalation, in contact with skin and if swallowed.
    S相 S: 36

    Wear suitable protective clothing.
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Harmful
    储存 -20°C
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

    merck millipore,默克密理博,203980,α-Bungarotoxin, Bungarus multicinctus - CAS 11032-79-4 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,693021,ZWITTERGENT 3-10 Detergent - CAS 15163-36-7 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,402176,ImmunoPen™


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