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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H WB Rb Purified Polyclonal Antibody 描述 产品目录编号 AB16529 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-MyD88 Antibody, internal sequence 产品信息 格式 Purified 演示 Purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide. 应用 应用 This Anti-MyD88 Antibody, internal sequence is validated for use in WB for the detection of MyD88. 主要应用 - Western Blotting
应用说明 Western blot: 1:500 to 1:1000
Whole cell lysate from Jurkat cells can be used as positive control and a 35 kDa band should be detected.
AB16529 cross reacts with mouse.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Rabbit anti-MyD88 (internal) polyclonal antibody was raised against a peptide corresponding to amino acids 233 to 248 of human MyD88 (Bonnert et al. 1997), which differ from those of mouse by two amino acids. 表位 internal sequence 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-RAcP. Recently, MyD88 was identified as an adapter molecule in the IL-1 signaling pathway (Muzio et al. 1997). MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R mediated NF-kB activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor (Adachi et al. 1998; Medzhitov et al. 1998), which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in loss of cellular responses to IL-1 and IL-18, and MyD88-defecient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues. 品种反应性 MouseHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_002468.3
基因符号 - MYD88
UniProt编号 - Q99836
UniProt汇总 FUNCTION: SwissProt: Q99836 # Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. May be involved in myeloid differentiation.
SIZE: 296 amino acids; 33233 Da
SUBUNIT: Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1 and IRAK2 via their respective TIR domains. Interacts with IL1RL1.
SUBCELLULAR LOCATION: Cytoplasm (Probable).
TISSUE SPECIFICITY: Ubiquitous.
SIMILARITY: SwissProt: Q99836 ## Contains 1 death domain. & Contains 1 TIR domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C in undiluted aliquots for up to 12 months. 包装信息 数量 100 µg
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