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  • merck millipore,默克密理博,ABE269,Anti-acetyl-Histone H2B (Lys24) Antibody

  • merck millipore,默克密理博,ABE269,Anti-acetyl-Histone H2B (Lys24) Antibody

    产品名称：Anti-acetyl-Histone H2B (Lys24) Antibody
    产品型号：ABE269
    Use Anti-acetyl-Histone H2B (Lys24) Antibody (Rabbit Polyclonal Antibody) validated in WB, IP, DB to detect acetyl-Histone H2B (Lys24) also known as H2BK24Ac, Histone H2B (acetyl K24).

    merck millipore,默克密理博,ABE269,Anti-acetyl-Histone H2B (Lys24) Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABE269,Anti-acetyl-Histone H2B (Lys24) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 ABE269
    描述 Anti-acetyl-Histone H2B (Lys24) Antibody
    Alternate Names
    • H2B type 12
    • Histone H2B type 3-B
    背景信息 Changes in chromatin structure play a large role in the regulation of transcription in eukaryotes (1). The nucleosome is the primary building block of chromatin, and is made up of four core histone proteins (H2A, H2B, H3 and H4) (2). Acetylation of core histones regulates gene expression (2). Histone H2B is primarily acetylated at lysines 5, 12, 15, and 20 (3). Ubiquitylation of Histone H2B at lysine 123 by Rad6 has been implicated in transcriptional activation and lysine methylation on histone H3 (4). Histone H2B phosphorylation at Ser10 (for yeast) and Ser14 (for mammalian cells) has been linked to regulation of apoptosis and meiosis (5).
    产品信息
    格式 Affinity Purified
    控制
    • Recombinant Histone H2B protein, and untreated and sodium butyrate treated HeLa acid extracts
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Use Anti-acetyl-Histone H2B (Lys24) Antibody (Rabbit Polyclonal Antibody) validated in WB, IP, DB to detect acetyl-Histone H2B (Lys24) also known as H2BK24Ac, Histone H2B (acetyl K24).
    主要应用
    • Western Blotting
    应用说明 Immunoprecipitation Analysis: 10 μg from a representative lot immunoprecipitated acetyl-Histone H2B (Lys24) from HeLa acid extract.

    Dot Blot Specificity Analysis: Unmodified and various modified Histone peptides (see Table) were probed with Anti-acetyl-Histone H2B (Lys24) (1:500 dilution).
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human Histone H2B acetylated at Lys24.
    表位 Acetylated Lys24
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes Histone H2B acetylated at Lys24.
    品种反应性 RatHumanMouse
    Species Reactivity Note Demonstrated to react with Human, Mouse, and Rat.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_001019770
    基因符号
    • HIST3H2BB
    纯化方法 Affinity purified
    UniProt编号
    • Q8N257
    产品使用声明
    质量保证 Evaluated by Western Blot in recombinant Histone H2B protein, and untreated and sodium butyrate treated HeLa acid extracts.

    Western Blot Analysis: A 1:500 dilution of this antibody detected Histone H2B on 10 µg of recombinant Histone H2B protein, and untreated and sodium butyrate treated HeLa acid extracts.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 200 µL

    merck millipore,默克密理博,ABE269,Anti-acetyl-Histone H2B (Lys24) Antibody

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