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merck millipore,默克密理博,SF-710,APC; Human, Cyanine 5, RNA Detection Probe,SmartFlare
产品名称：APC; Human, Cyanine 5, RNA Detection Probe, SmartFlare
产品型号：SF-710
Use SmartFlare RNA Detection probes to measure gene expression in live cells. With an overnight incubation of SmartFlare APC, Human, Cyanine 5, you can detect APC RNA levels within your cells.
merck millipore,默克密理博,SF-710,APC; Human, Cyanine 5, RNA Detection Probe,SmartFlare
- 产品介绍
重要规格表
Entrez Gene Number Species Reactivity Species Reactivity Note NM_000038.5 H NM_00127511.2, NM_001127510.2 描述 产品目录编号 SF-710 商名 - SmartFlare
描述 APC; Human, Cyanine 5, RNA Detection Probe | SmartFlare Alternate Names - DP3
- GS
- DP2
背景信息 With SmartFlare™ RNA Detection probes, you can detect RNA in LIVE CELLS with ease. With just an overnight incubation of APC; Human, Cyanine 5, RNA Detection Probe you can detect the presence of APC within your cells.
Colon cancer generally occurs sporadically although there is clear genetic predisposition in some families. Familial Adenomatous Polyposis Coli (FAP) is an autosomal dominantly inherited disorder that exhibits 80 to 100% penetrance and predisposes to colon cancer. The gene responsible for FAP has been assigned to chromosome 5q21, a region that is often lost in tumors from patients with sporadic colorectal cancer. Recently, a gene called APC, for adenomatous polyposis coli, from the 5q21 locus was isolated and shown to contain mutations in DNA prepared from tumors of patients with sporadic colorectal cancer and in germ line DNA and tumor DNA from FAP patients. In 79 unrelated patients with FAP, mutations in APC were found in 67% of the cases; and 49 of the 53 mutations were either small deletions/insertion or were point mutations that introduced stop codons into the reading frame. Furthermore, APC mutations have been found in the earliest tumors that could be analyzed (0.5 cm diameter) and the mutation frequency remained constant as tumors progressed from benign to malignant stages. Analysis of the APC protein demonstrates that inactivating mutations result in stable truncated proteins that can be identified in colon tumors from both FAP and sporadic colon cancer patients as well as in constitutional cells of FAP patients. Loss of heterozygosity at the APC locus has also been reported for esophageal cancer and lung cancer.产品信息 格式 Cyanine 5 演示 Lyophilized 应用 应用 Use SmartFlare RNA Detection probes to measure gene expression in live cells. With an overnight incubation of SmartFlare APC, Human, Cyanine 5, you can detect APC RNA levels within your cells. 主要应用 - RNA Detection
生物信息 品种反应性 Human Species Reactivity Note NM_00127511.2, NM_001127510.2 Entrez基因编号 - NM_000038.5
基因符号 - APC
产品使用声明 质量保证 SmartFlare Probes have been tested in a buffer system to detect the release of the fluorophore in the presence of a complimentary base pair sequence for each lot to confirm target specificity. SmartFlare Probes have also been tested in a cell model system and demonstrated increased fluorescence in cells expressing the target compared to a negative SmartFlare Scramble Control. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Store at 2–8°C in lyophilized format ONLY. Room temperature is required for reconstituted product. 包装信息 数量 250 reactions
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