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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABC102 描述 Anti-CCN1/CYR61 Antibody Alternate Names - Protein GIG1
- Protein CYR61
- CCN family member 1
- Cysteine-rich angiogenic inducer 61
- Insulin-like growth factor-binding protein 10
- IBP-10
- IGF-binding protein 10
- IGFBP-10
背景信息 CCN1 (cysteine-rich 61 or CYR61), a ubiquitous angiogenic factor, is a member of the CNN family, which is also comprised of CTGF, WISP-1, WISP-2, and WISP-3. It is a multidomain protein, containing one each of CTCK, IGFBP, TSP type-1, and VWFC domains. CCN1 is associated with the extracellular matrix and functions as a ligand for integrin receptors. It is expressed in response to growth factor stimulation, and mediates various cellular processes, including cell adhesion, migration, proliferation, angiogenesis, extracellular-matrix remodeling, and placental development. Previous studies have indicated that it may also play a role in wound healing by influencing the expression of genes required for this process, such as TIMP1, PAI-1, VEGA-A, VEGA-C, MMP1, MMP3, and uPA. CCN1 has also been implicated in breast cancer. 产品信息 格式 Affinity Purified 控制 - NIH/3T3 cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect CCN1/CYR61 using this Anti-CCN1/CYR61 Antibody validated for use in Western Blotting, IHC(P). 主要应用 - Western Blotting
应用说明 Immunohistochemistry Analysis: 1:200 dilution from a representative lot detected CCN1/CYR61 in human kidney tissue. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the CTCK domain of human CCN1/CYR61. 表位 CTCK domain 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes the CTCK domain of: CCN1/CYR61 品种反应性 RatHumanMouse Species Reactivity Note Demonstrated to react with Human, Mouse, and Rat. Predicted to react with Chimpanzee based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_001545
基因符号 - IGFBP10
- CYR61
- CCN1
- GIG1
纯化方法 Antigen Affinity purified UniProt编号 - O00622
产品使用声明 质量保证 Evaluated by Western Blot in NIH/3T3 cell lysate.
Western Blot Analysis: 2 µg/mL of this antibody detected CCN1/CYR61 in 10 µg of NIH/3T3 cell lysate.
使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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