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merck millipore,默克密理博,MTH17MAG-47K,MILLIPLEX MAP Mouse TH17 Magnetic Bead Panel - Immunology Multiplex Assay
产品名称：MILLIPLEX MAP Mouse TH17 Magnetic Bead Panel - Immunology Multiplex Assay
产品型号：MTH17MAG-47K
The analytes available for this multiplex kit are: CD40 Lig&, GM-CSF, IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12 (p70), IL-13, IL-15, IL-17A, IL-17E/IL-25, IL-17F, IL-21, IL-22, IL-23, IL-27, More>>
merck millipore,默克密理博,MTH17MAG-47K,MILLIPLEX MAP Mouse TH17 Magnetic Bead Panel - Immunology Multiplex Assay
- 产品介绍
- merck millipore,默克密理博,MTH17MAG-47K,MILLIPLEX MAP Mouse TH17 Magnetic Bead Panel - Immunology Multiplex Assay
重要规格表
可用的分析物 品种反应性 主要应用 检测方法 IL-6, IL-10, IL-12 (p70), IL-13, IL-15, IL-17A, IL-17E/IL-25, IL-17F, IL-21, IL-22, IL-23, IL-27, IL-28B, IL-31, IL-33, MIP-3α/CCL20, TNF-α, TNFβ, CD40 Ligand, GM-CSF, IFN-γ, IL-1β, IL-2, IL-4, IL-5 M Mplex Luminex xMAP 描述 产品目录编号 MTH17MAG-47K 商名 - MILLIPLEX
描述 MILLIPLEX MAP Mouse TH17 Magnetic Bead Panel - Immunology Multiplex Assay 概述 The MILLIPLEX MAP Mouse Th17 Magnetic Bead panel enables you to focus on the therapeutic potential of the modulation of CD4 T-helper cell cytokines. Coupled with the Luminex® xMAP® platform in a magnetic bead format, you receive the advantage of ideal speed and sensitivity, allowing quantitative multiplex detection of dozens of analytes simultaneously, which can dramatically improve productivity. 背景信息 CD4 T-helper cells are major players in adaptive immunity. Based on their expression profile of transcription factors and secreted cytokines, these cells are divided into the major subsets Th1, Th2, Th17 and T regulatory (Treg) cells. Th1 cells, induced by IL-12 and enhanced by IFN, secrete IFN that activates macrophages. Induced by IL-4, Th2 cells primarily produce IL-4, IL-5, IL-13, IL-25 and IL-17E, playing a role in allergy. Treg cells, induced by TGFβ, produce the anti-inflammatory cytokines IL-10 and TGFβ and function to control T-cell responses to prevent autoimmune reactions. Th17 cells, a more recently discovered subset characterized by the production of IL-17, are induced by TGFβ combined with IL-23 and IL-1β in humans, and TGFβ, IL-6 and IL-21 in mice. Activated Th17 cells secrete IL-17A, IL-17F, IL-21, IL-22 and TNFα to promote tissue inflammation.
Th17 cells are involved in the clearance of extracellular bacteria and fungi. They are abundant in the intestinal lamina propria and function as a barrier against invading pathogens. Excessive amounts of Th17 cells have been implicated in the pathogenesis of several autoimmune diseases, including multiple sclerosis, psoriasis, juvenile diabetes, rheumatoid arthritis, Crohn's disease and autoimmune uveitis. In addition Th17 cells play an important role in tumor development, progression and metastasis, potentially in both promoting and inhibiting tumor growth.产品信息 检测方法 Luminex xMAP 配置 Design your multiplex kit by choosing analytes. 精度（%） - Intra-assay:< 10
- Inter-assay: < 15
板面类型 MAGNETIC Cytokines/Chemokines 应用 应用 The analytes available for this multiplex kit are: CD40 Lig&, GM-CSF, IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12 (p70), IL-13, IL-15, IL-17A, IL-17E/IL-25, IL-17F, IL-21, IL-22, IL-23, IL-27, IL-28B, IL-31, IL-33, MIP-3α/CCL20, TNFα, TNFβ. 主要应用 - Multiplexing
应用说明 • This is a two-hour or overnight incubation assay requiring 25 µL of neat plasma or serum, or 25 μL cell culture supernatant per well.
• This kit may be used for the analysis of all or any combination of the Th17 panel analytes in serum, plasma or tissue/cell lysate and culture supernatant生物信息 品种反应性 Mouse 可用的分析物 - IL-6
- IL-10
- IL-12 (p70)
- IL-13
- IL-15
- IL-17A
- IL-17E/IL-25
- IL-17F
- IL-21
- IL-22
- IL-23
- IL-27
- IL-28B
- IL-31
- IL-33
- MIP-3α/CCL20
- TNF-α
- TNFβ
- CD40 Ligand
- GM-CSF
- IFN-γ
- IL-1β
- IL-2
- IL-4
- IL-5
交叉反应性 There was no or minimum cross-reactivity between the antibodies and any other analytes in the panel (see details in assay protocol). 理化信息 灵敏度 - Refer to kit protocol for sensitivities of individual biomarkers.
稀释的线性 1:8 113.1% 标准曲线范围 - TNFα: 3.4 – 3,500 pg/mL
- CD40L IL-31 & MIP-3α: 49 – 50,000 pg/mL
- GM-CSF & IL-15: 34 – 35,000 pg/mL
- IFNγ & IL-6: 7.8 – 8,000 pg/mL
- IL-1β: 15 – 15,000 pg/mL
- IL-2: 6.9 – 6,000 pg/mL
- IL-4: 1.5 – 1,500 pg/mL
- IL-5: 4.9 – 5,000 pg/mL
- IL-10, IL-12(p70), & IL-21:20 – 20,000 pg/mL
- IL-13 & IL-17A: 39 – 40,000 pg/mL
- IL-17E/ IL-25: 586 – 600,000 pg/mL
- IL-17F: 10 – 10,000 pg/mL
- IL-22: 2.4 – 2,500 pg/mL
- IL-23: 342 -350,000 pg/mL
- IL-27: 879 – 900,000 pg/mL
- IL-28B: 127 – 130,000 pg/mL
- IL-33: 78 – 80,000 pg/mL
- TNFβ:488 – 500,000 pg/mL
产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Recommended storage for kit components is 2 - 8°C. 包装信息 数量 96-well plate
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