• merck millipore,默克密理博,MABT67,Anti-L-Selectin (CD62L) Antibody, clone MEL-14
  • merck millipore,默克密理博,MABT67,Anti-L-Selectin (CD62L) Antibody, clone MEL-14

    产品名称:Anti-L-Selectin (CD62L) Antibody, clone MEL-14
    产品型号:MABT67
    Anti-L-Selectin (CD62L) Antibody, Clone MEL-14 is an antibody against L-Selectin (CD62L) for use in FC, IH & IF.

    merck millipore,默克密理博,MABT67,Anti-L-Selectin (CD62L) Antibody, clone MEL-14

  • 产品介绍
  • merck millipore,默克密理博,MABT67,Anti-L-Selectin (CD62L) Antibody, clone MEL-14

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    MIHC, FCRPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABT67
    描述 Anti-L-Selectin (CD62L) Antibody, clone MEL-14
    Alternate Names
    • CD62L antigen
    • selectin L
    • Leukocyte-endothelial cell adhesion molecule 1
    • CD62 antigen-like family member L
    • lymphocyte adhesion molecule 1
    • Lyam-1
    • Leukocyte adhesion molecule 1
    • pln homing receptor
    • Leukocyte surface antigen Leu-8
    • L-selectin
    • Lymph node homing receptor
    背景信息 L-selectin (CD62L) expression improves immune surveillance by encoding CD4+ T cell blood and lymph node spreading. Increased expression of CD62L has been linked to increased stress and certain panic disorders. It has been shown that CD4+ cells expressing CD62L can prevent the onset of diabetes. Subjects with cryptococcosis have been shown to have more soluble CD62L in the serum. The inability to get rid of CD62L may enhance leukocyte-mediated end-organ injury in patients with sepsis.
    产品信息
    格式 Purified
    控制
    • C57BL6 mouse splenocytes
    演示 Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-L-Selectin (CD62L) Antibody, Clone MEL-14 is an antibody against L-Selectin (CD62L) for use in FC, IH & IF.
    主要应用
    • Immunohistochemistry
    • Flow Cytometry
    应用说明 Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH (Reichert, R., et al. (1986). J Immunol. 136:3535-3542).

    Immunofluorescence Analysis: A previous lot was used by an independent laboratory in IF (Reichert, R., et al. (1986). J Immunol. 136:3535-3542).
    生物信息
    免疫原品种 38C-13 B cell lymphoma cell lines derived from a C3H/eb mouse.
    克隆 MEL-14
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rat
    同种型 IgG2aκ
    品种反应性 Mouse
    Species Reactivity Note Demonstrated to react with mouse.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_035476
    基因符号
    • LEU8
    • LAM1
    • LECAM1
    • LNHR
    • TQ1
    • LYAM1
    • gp90-MEL
    • LSEL
    • Leu-8
    • PLNHR
    • hLHRc
    • CD62L
    • LAM-1
    纯化方法 Protein G Purified
    UniProt编号
    • P18337
    UniProt汇总 FUNCTION: Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (By similarity).

    SUBUNIT STRUCTURE: Interaction with PSGL1/SELPLG is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan and tyrosine sulfation modifications of PSGL1. Probable sulfation on Y-54 of PSGL1 is most important for L-selectin binding.

    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

    TISSUE SPECIFICTY: Predominantly expressed in lymphoid tissue.

    SEQUENCE SIMILARITIES: Belongs to the selectin/LECAM family.

    Contains 1 C-type lectin domain.

    Contains 1 EGF-like domain.

    Contains 2 Sushi (CCP/SCR) domains.
    产品使用声明
    质量保证 Evaluated by Flow Cytometry in C57BL6 mouse splenocytes.

    Flow Cytometry Analysis: 2 µg of this antibody detected L-Selectin (CD62L) in C57BL6 mouse splenocytes.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABT67,Anti-L-Selectin (CD62L) Antibody, clone MEL-14

上一件merck millipore产品:merck millipore,默克密理博,07-1534,Anti-JMJD3 Antibody (CT)
下一件merck millipore产品:merck millipore,默克密理博,06-1037,Anti-TMEM126A Antibody



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