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merck millipore,默克密理博,07-1534,Anti-JMJD3 Antibody (CT)
产品名称：Anti-JMJD3 Antibody (CT)
产品型号：07-1534
Anti-JMJD3 Antibody (C-terminus) is a Rabbit Polyclonal Antibody for detection of JMJD3 Antibody (C-terminus) also known as JmjC domain-containing protein 3 & has been validated in ICC, ELISA & WB.
merck millipore,默克密理博,07-1534,Anti-JMJD3 Antibody (CT)
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H WB, ICC, ELISA Rb Purified Polyclonal Antibody 描述 产品目录编号 07-1534 描述 Anti-JMJD3 Antibody (CT) Alternate Names - jumonji domain containing 3, histone lysine demethylase
- JMJD
- JmjC domain-containing protein 3
- Jumonji domain-containing protein 3
- Lysine demethylase 6B
- jumonji domain containing 3
- JMJD
背景信息 JMJD3 (Jumonji domain-containing protein 3) is part of the family of novel JmjC domain-containing histone demethylation (JHDM) enzymes. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. JMJD3 specifically demethylates Lys27 on histone H3, demethylating both the trimethylated and dimethylated form. JMJD3 plays a role in the regulation of posterior development by regulating HOX gene expression. It is also involved in the inflammatory response by regulating gene expression and macrophage differentiation 产品信息 格式 Purified 控制 - HeLa cells, NIH/3T3 cells
演示 Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. 应用 应用 Anti-JMJD3 Antibody (C-terminus) is a Rabbit Polyclonal Antibody for detection of JMJD3 Antibody (C-terminus) also known as JmjC domain-containing protein 3 & has been validated in ICC, ELISA & WB. 主要应用 - Western Blotting
- Immunocytochemistry
- ELISA
应用说明 Western Blot Analysis:
This antibody is reported by an
outside laboratory to be suitable for Western blotting
ELISA:
This antibody is reported by an
outside laboratory to be suitable for ELISA
生物信息 免疫原品种 This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of murine JMJD3. 表位 C-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes the C-terminal region of murine JMJD3. Additional non-specific, lower molecular weight bands are detected in some lysates. 品种反应性 MouseHuman Species Reactivity Note Human and mouse. Not tested in other species. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_001017426
基因符号 - KIAA0346
- EC 1.14.11
- KDM6B
纯化方法 Protein G chromatography UniProt编号 - O15054
UniProt汇总 FUNCTION: Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. Ref.5 Ref.6
Cofactor Ascorbate By similarity.
Fe(2+). Ref.5
SUBUNIT STRUCTURE: Interacts with TLE1 By similarity. Component of the MLL4 complex, at least composed of MLL4, ASH2L, RBBP5, WDR5, and JMJD3.
SUBCELLULAR lOCATION: NucleusProbable.
INDUCTION: By 12-O-tetradecanoylphorbol-13-acetate (TPA) in myeloid leukemia cells. Ref.4
SIMILARITY: Belongs to the UTX family.
Contains 1 JmjC domain.
产品使用声明 质量保证 Immunocytochemisty:
Recognizes JMJD3 in NIH 3T3 and A431 cells by cytochemistry.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial to pellet the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
包装信息 数量 100 µg
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