merck millipore,默克密理博,MABT147,Anti-MMP-12 (CT) Antibody, clone EP1261Y, rabbit monoclonal

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merck millipore,默克密理博,MABT147,Anti-MMP-12 (CT) Antibody, clone EP1261Y, rabbit monoclonal
产品名称：Anti-MMP-12 (CT) Antibody, clone EP1261Y, rabbit monoclonal
产品型号：MABT147
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Detect MMP-12 (C-terminus) using this Anti-MMP-12 (C More>>

merck millipore,默克密理博,MABT147,Anti-MMP-12 (CT) Antibody, clone EP1261Y, rabbit monoclonal

产品介绍

merck millipore,默克密理博,MABT147,Anti-MMP-12 (CT) Antibody, clone EP1261Y, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
R, H, M	FC, WB, ICC	Rb	Diluted Culture Supernatant	Monoclonal Antibody

描述
产品目录编号	MABT147
描述	Anti-MMP-12 (CT) Antibody, clone EP1261Y, rabbit monoclonal
Alternate Names	macrophage metalloelastase matrix metallopeptidase 12 (macrophage elastase) matrix metalloproteinase 12 (macrophage elastase) Macrophage elastase Matrix metalloproteinase-12
背景信息	Human macrophage elastase (MMP-12) is a member of the family of matrix metalloproteinases (MMPs) that plays, like other members of the family, an important role in inflammatory processes contributing to tissue remodeling and destruction. In particular, a prominent role of MMP-12 in the destruction of elastin in the lung alveolar wall and the pathogenesis of emphysema has been suggested (1). MMP-12 expressed mainly in alveolar macrophages has been identified in the mouse lung as the main destructive agent associated with cigarette smoking, which gives rise to emphysema, both directly via elastin degradation and indirectly by disturbing the proteinase/antiproteinase balance via inactivation of the alpha1-proteinase inhibitor (alpha1-PI), the antagonist of the leukocyte elastase (2). Because elastin represents a critical component of aortic wall structure and a matrix substrate for metalloelastases, MMP-12 may have a direct and singular role in the pathogenesis of aortic aneurysms (3).

产品信息
格式	Diluted Culture Supernatant
控制	Recombinant MMP-12 protein
演示	Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Detect MMP-12 (C-terminus) using this Anti-MMP-12 (C-terminus) Antibody, clone EP1261Y, Rabbit validated for use in WB, IC, IH(P), FC & IP.
主要应用	Flow Cytometry Western Blotting Immunocytochemistry
应用说明	Immunoprecipitation Analysis: 1:30 dilution from a representative lot was used in IP. Flow Cytometry Analysis: 1:10 dilution from a representative lot was used in FC. Immunohistochemistry Analysis: 1:100-1:250 dilution from a representative lot detected MMP-12 in human breast carcinoma tissue. Immunocytochemistry Analysis: 1:100-250 dilution from a representative lot was used to detect MMP-12 in HeLa cells.

生物信息
免疫原品种	Synthetic peptide corresponding to human MMP-12 at the C-terminus.
克隆	EP1261Y
宿主	Rabbit
特异性	This antibody recognizes MMP-12 at the C-terminus.
同种型	IgG
品种反应性	RatHumanMouse
Species Reactivity Note	Demonstrated to react with human, mouse, and rat.
抗体类型	Monoclonal Antibody
基因符号	EC 3.4.24.65 HME MME MMP-12 ME MGC138506 hME
纯化方法	Unpurified
UniProt编号	P39900

产品使用声明
质量保证	Evaluated by Western Blot in recombinant MMP-12 protein. Western Blot Analysis: 1:2,000 dilution of this antibody detected MMP-12 in recombinant MMP-12 protein.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing Solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below
-20°C may cause glycerol containing Solutions to become frozen during storage.