merck millipore,默克密理愽
  • merck millipore,默克密理博,07-1829,Anti-phospho-NF-kB (p100) (Ser707) Antibody

  • merck millipore,默克密理博,07-1829,Anti-phospho-NF-kB (p100) (Ser707) Antibody

    产品名称：Anti-phospho-NF-kB (p100) (Ser707) Antibody
    产品型号：07-1829
    Use Anti-phospho-NF-kB (p100) (Ser707) Antibody (Rabbit Polyclonal Antibody) validated in WB, PIA, DB to detect phospho-NF-kB (p100) (Ser707) also known as Nuclear factor NF-kappa-B p100 subunit or H2 More>>

    merck millipore,默克密理博,07-1829,Anti-phospho-NF-kB (p100) (Ser707) Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-1829,Anti-phospho-NF-kB (p100) (Ser707) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-1829
    描述 Anti-phospho-NF-kB (p100) (Ser707) Antibody
    Alternate Names
    • Nuclear factor NF-kappa-B p52 subunit
    • Nuclear factor NF-kappa-B p100 subunit
    • DNA-binding factor KBF2
    • H2TF1
    • Lymphocyte translocation chromosome 10 protein
    • Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
    • Oncogene Lyt-10
    • Lyt10
    背景信息 NF-kappa-B (NF-kB) is a family of ubiquitous transcription factors, which includes RelA, RelB, NF-kB1 and NF-kB2. The NF-kB family regulates multiple cellular processes, including cell growth, differentiation, inflammation, immunity, and apoptosis. In general, inactive forms of NF-kB proteins, bound by IkappaB inhibitory proteins, are present in the cytoplasm, whereas activated forms translocate to the nucleus where they exert transcriptional activity. The p100 subunit is an inactive precursor of NF-kB2, and is proteolyzed to generate the functional p52 protein and enable the formation of an active NF-kB2/p52 dimeric complex. The processing of p100 to form p52 is induced by the NF-kappaB-inducing kinase (NIK), which recruits IkappaB kinase alpha to p100, resulting in phosphorylating of p100 at serines 99, 108, 115, 123, and 872, which is required for subsequent ubiquitination and processing of p100 by the beta-TrCP ubiquitin ligase. Nuclear p100 is phosphorylated at serine 707 by GSK3, which promotes its degradation by Fbxw7α.
    产品信息
    格式 Affinity Purified
    控制
    • Phosphorylated and non-phosphorylated NF-kB peptides
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Use Anti-phospho-NF-kB (p100) (Ser707) Antibody (Rabbit Polyclonal Antibody) validated in WB, PIA, DB to detect phospho-NF-kB (p100) (Ser707) also known as Nuclear factor NF-kappa-B p100 subunit or H2TF1.
    主要应用
    • Western Blotting
    应用说明 Peptide Inhibition Analysis: A 1:500 dilution from a representative lot blocked phospho-NF-kB (p100) (Ser707) in non-starved HEK293 cell lysates.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human NF-kB (p100) phosphorylated at Ser707.
    表位 Phosphorylated Ser707
    宿主 Rabbit
    特异性 This antibody recognizes NF-kB (p100) phosphorylated at Ser707.
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with Human.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_002493
    基因符号
    • LYT10
    • NFKB2
    纯化方法 Affinity purified
    UniProt编号
    • Q00653
    产品使用声明
    质量保证 Dot Blot Specificity Analysis: Phosphorylated and non-phosphorylated NF-kB peptides (see Table) were probed with Anti-phospho-NF-kB (p100) (Ser707) (1:500 dilution).
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 200 µL

    merck millipore,默克密理博,07-1829,Anti-phospho-NF-kB (p100) (Ser707) Antibody

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