- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M WB Rb Purified Polyclonal Antibody 描述 产品目录编号 AB1673 Replaces AB3385P 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Leptin Antibody 产品信息 格式 Purified 演示 Purified immunoglobulin in PBS. Contains no preservative. 应用 应用 Anti-Leptin Antibody detects level of Leptin & has been published & validated for use in RIA & WB. 主要应用 - Western Blotting
应用说明 Western blot: 1:1,000
RIA: 1:1,000
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Recombinant mouse leptin. 宿主 Rabbit 特异性 Reacts with mouse leptin. 品种反应性 Mouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_002303.3
- NM_001003679.1
- NM_001003680.1
Entrez基因汇总 Leptin (LEP; MIM 164160), an adipocyte-specific hormone that regulates adipose-tissue mass through hypothalamic effects on satiety and energy expenditure, acts through the leptin receptor (LEPR), a single-transmembrane-domain receptor of the cytokine receptor family.[supplied by OMIM] 基因符号 - HuB219
- LEPR
- DB
- OBR
- CD295
- OB-R
- LEP-R
UniProt编号 - P48357
UniProt汇总 FUNCTION: SwissProt: P48357 # Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity).
SIZE: 1165 amino acids; 132494 Da
SUBUNIT: On leptin stimulation, homodimerizes. The phosphorylated receptor binds a number of SH2 domain-containing proteins such as STAT3, PTPN11, and SOCS3 (By similarity). Interaction with SOCS3 inhibits LRb signaling (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. & Isoform E: Secreted (Probable).
TISSUE SPECIFICITY: Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus.
DOMAIN: SwissProt: P48357 The cytoplasmic domain may be essential for intracellular signal transduction by activation of JAK tyrosine kinase and STATs. & The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding. & The box 1 motif is required for JAK interaction and/or activation.
PTM: On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-986 is required for complete binding and activation of PTPN11, ERK/FOS activation and, for interaction with SOCS3 (By similarity). Phosphorylation on Tyr-1141 is required for STAT3 binding/activation.
SIMILARITY: Belongs to the type I cytokine receptor family. Type 2 subfamily. & Contains 4 fibronectin type-III domains. & Contains 1 Ig-like (immunoglobulin-like) domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in diluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
上一件merck millipore产品：merck millipore,默克密理博,17-10199,ChIPAb+™ HDAC1 Antibody, rabbit monoclonal
下一件merck millipore产品：merck millipore,默克密理博,GF169,BMP-7 Protein, Human Recombinant
相关产品
merck millipore,默克密理博,AB3265,Anti-Actin γ Antibody
merck millipore,默克密理博,09-454,Anti-Dock2 Antibody
merck millipore,默克密理博,SF-1324,BCL2L2; Human, Cyanine 5 RNA Detection Probe,SmartFlare
merck millipore,默克密理博,07-1829,Anti-phospho-NF-kB (p100) (Ser707) Antibody
merck millipore,默克密理博,17-10199,ChIPAb+™ HDAC1 Antibody, rabbit monoclonal
merck millipore,默克密理博,GF169,BMP-7 Protein, Human Recombinant
merck millipore,默克密理博,FCMAB170F,Milli-Mark Anti-CD4 -FITC Antibody, clone MT310
merck millipore,默克密理博,HTS000MC,ChemiSCREEN™ CHO Membrane Preparation, Null Control
merck millipore,默克密理博,MAB6021,Anti-Cytochrome P450 Aldosterone Synthase Antibody, clone 1G5