merck millipore,默克密理博,MABS753,Anti-RBX1, clone EPR6849(B), Rabbit Monoclonal Antibody

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merck millipore,默克密理博,MABS753,Anti-RBX1, clone EPR6849(B), Rabbit Monoclonal Antibody
产品名称：Anti-RBX1, clone EPR6849(B), Rabbit Monoclonal Antibody
产品型号：MABS753
This Anti-RBX1, clone EPR6849(B), Rabbit Monoclonal Antibody is validated for use in Western Blotting for the detection of RBX1.

merck millipore,默克密理博,MABS753,Anti-RBX1, clone EPR6849(B), Rabbit Monoclonal Antibody

产品介绍

merck millipore,默克密理博,MABS753,Anti-RBX1, clone EPR6849(B), Rabbit Monoclonal Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	WB	Rb	Unpurified	Monoclonal Antibody

描述
产品目录编号	MABS753
描述	Anti-RBX1, clone EPR6849(B), Rabbit Monoclonal Antibody
Alternate Names	Regulator of cullins 1 E3 ubiquitin-protein ligase RBX1 EC 6.3.2.- Protein ZYP RING finger protein 75 RING-box protein 1 Rbx1
背景信息	RING-box protein 1 RBX1 is an evolutionarily conserved protein that interacts with cullins. It plays a unique role in the ubiquitination reaction by forming a heterodimer with cullin-1 to catalyze ubiquitin polymerization. It also may be involved in the regulation of protein turn-over. RBX1 is a component of the SCF (SKP1-CUL1-F-box protein) and the CBC(VHL) (CUL2-elonging BC-VHL) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, RBX1 seems to recruit the E2 ubiquitination enzyme CDC34 to the complex and brings it into close proximity to the substrate and probably stimulates CDC34 autoubiquitination. It promotes the neddylation of CUL1 and probably CUL2. RBX1 may be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair.

产品信息
格式	Unpurified
演示	Rabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol.

应用
应用	This Anti-RBX1, clone EPR6849(B), Rabbit Monoclonal Antibody is validated for use in Western Blotting for the detection of RBX1.
主要应用	Western Blotting
应用说明	Produced in collaboration with Epitomics™

生物信息
免疫原品种	Synthetic peptide corresponding to the N-terminus of human RBX1.
表位	N-terminus
克隆	EPR6849(B)
浓缩	Please refer to lot specific datasheet.
宿主	Rabbit
同种型	IgG
品种反应性	Human
Species Reactivity Note	Human
抗体类型	Monoclonal Antibody
基因符号	ROC1 RBX1 RNF75
纯化方法	Unpurified
UniProt编号	P62877

产品使用声明
质量保证	Evaluated by Western Blotting in HepG2, Jurkat and HeLa cell lysates. Western Blotting Analysis: A 1:1,000-10,000 dilution of this antibody detected RBX1 in HepG2, Jurkat and HeLa cell lysates.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.