merck millipore,默克密理愽
  • merck millipore,默克密理博,MABS67,Anti-erbB-3/HER-3 Antibody, clone 15A2.1

  • merck millipore,默克密理博,MABS67,Anti-erbB-3/HER-3 Antibody, clone 15A2.1

    产品名称：Anti-erbB-3/HER-3 Antibody, clone 15A2.1
    产品型号：MABS67
    This Anti-erbB-3/HER-3 Antibody, clone 15A2.1 is validated for use in WB, IC for the detection of erbB-3/HER-3.

    merck millipore,默克密理博,MABS67,Anti-erbB-3/HER-3 Antibody, clone 15A2.1

  • 产品介绍
  • merck millipore,默克密理博,MABS67,Anti-erbB-3/HER-3 Antibody, clone 15A2.1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HICC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABS67
    描述 Anti-erbB-3/HER-3 Antibody, clone 15A2.1
    Alternate Names
    • Tyrosine kinase-type cell surface receptor HER3
    • Receptor tyrosine-protein kinase erbB-3
    • Proto-oncogene-like protein c-ErbB-3
    背景信息 erbB-3/HER-3 is a receptor tyrosine kinase (RTK) and is a member of the EGFR/ErbB family of receptor tyrosine kinases. Four subfamilies make up the ErbB family of receptors: erbB-1 (EGFR), erbB-2 (HER2/c-neu), erbB-3 (HER3), and erbB-4 (HER4). erbB-2 is membrane bound and able to bind its ligand, but it does not have an active kinase domain to transmit this signal. In order to transmit the signal, erbB-3 must first form a heterodimer with other ErbB family memebers. This heterodimerization then leads to proliferation and differentiation. erbB-2 also binds Phosphoinositide 3 Kinase (PI3K) through six tyrosine phosphorylation sites that PI3K can bind resulting in the activation of AKT/PKB. erbB-3 has been shown to be amplified in numerous types of cancer, including breast and prostate.
    产品信息
    格式 Purified
    控制
    • MCF-7 cell lysate
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This Anti-erbB-3/HER-3 Antibody, clone 15A2.1 is validated for use in WB, IC for the detection of erbB-3/HER-3.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Western Blot Analysis: 0.5 µg/mL from a representative lot detected erbB-3/HER-3 on 10 µg of NIH/3T3 cell lysate.
    生物信息
    免疫原品种 GST-tagged recombinant protein corresponding to human erbB-3/HER-3.
    克隆 15A2.1
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG1κ
    品种反应性 MouseHuman
    Species Reactivity Note Demonstrated to react with Human and Mouse.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001005915
    Entrez基因汇总 This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
    基因符号
    • HER3
    • ERBB3
    纯化方法 Protein G purified
    UniProt编号
    • P21860
    UniProt汇总 FUNCTION: Binds and is activated by neuregulins and NTAK.

    SIZE: 1342 amino acids; 148098 Da

    SUBUNIT: Heterodimer with each of the other ERBB receptors (Potential). Interacts with CSPG5 and PA2G4.

    SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.

    TISSUE SPECIFICITY: Epithelial tissues and brain.

    DOMAIN: The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.

    PTM: Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (By similarity).

    DISEASE: Overexpressed in a subset of human mammary tumors. & Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2) [MIM:607598]; also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord. The LCCS2 syndrome is characterized by multiple joint contractures, anterior horn atrophy in the spinal cord, and a unique feature of a markedly distended urinary bladder. The phenotype suggests a spinal cord neuropathic etiology.

    SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 Evaluated by Western Blot in MCF-7 cell lysate.

    Western Blot Analysis: 0.5 µg/mL of this antibody detected erbB-3/HER-3 on 10 µg of MCF-7 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABS67,Anti-erbB-3/HER-3 Antibody, clone 15A2.1

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