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merck millipore,默克密理博,492905,Nucleozin - Calbiochem
产品名称：Nucleozin - Calbiochem
产品型号：492905
A cell-permeable isoxazolylpiperazine compound that is shown to inhibit influenza A H1N1 (A/WSN/33 strain), H3N2 (clinical isolate), and H5N1 (A/Vietnam/1194/04) replication in MDCK cells.
merck millipore,默克密理博,492905,Nucleozin - Calbiochem
- 产品介绍
重要规格表
经验配方 C₂₁H₁₉ClN₄O₄ 描述 概述 A cell-permeable isoxazolylpiperazine compound that is shown to inhibit influenza A H1N1 (A/WSN/33 strain), H3N2 (clinical isolate), and H5N1 (A/Vietnam/1194/04) replication in MDCK cells in vitro (EC50 = 69, 160, and 330 nM, respectively) and significantly reduce fatality after A/Vietnam/1194/04 infection in mice in vivo (50% survial rate on day 21 with 14 b.i.d. i.p. doses of 230 µg/mouse in the first 7 days after infection) by preventing nucleoprotein (NP) nuclear accumulation via NP aggregation induction during early stages of viral infection. Virus strains with N309K or Y289H NP mutation, such as swine-origin influenza A (S-OIV) H1N1, are found to be resistant to Nucleozin, consistent with the N309-mediated hydrogen bonding and Y289-mediated hydrophobic interaction with Nucleozin as predicted by computer-aided docking studies. 产品目录编号 492905 品牌系列 Calbiochem®
参考 参考 Kao, R.Y., et al. 2010. Nat. Biotechnol. 28, 600. 产品信息 形式 Yellow powder Hill配方 C₂₁H₁₉ClN₄O₄ 化学配方 C₂₁H₁₉ClN₄O₄ Molar Mass 426.9 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 +2°C to +8°C
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C).
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