merck millipore,默克密理愽
  • merck millipore,默克密理博,521237,PDGFR Tyrosine Kinase Inhibitor VII - CAS 251356-45-3 - Calbiochem

  • merck millipore,默克密理博,521237,PDGFR Tyrosine Kinase Inhibitor VII - CAS 251356-45-3 - Calbiochem

    产品名称：PDGFR Tyrosine Kinase Inhibitor VII - CAS 251356-45-3 - Calbiochem
    产品型号：521237
    The PDGFR Tyrosine Kinase Inhibitor VII, also referenced under CAS 251356-45-3, controls the biological activity of PDGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphory More>>

    merck millipore,默克密理博,521237,PDGFR Tyrosine Kinase Inhibitor VII - CAS 251356-45-3 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,521237,PDGFR Tyrosine Kinase Inhibitor VII - CAS 251356-45-3 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₄H₂₂N₂O₃251356-45-3
    描述
    概述 A cell-permeable indolinone compound that acts as a potent, ATP site-targeting PDGFR inhibitor (IC50 = 10 nM against PDGFRβ), while affecting Flk-1/KDR/ VEGFR2, FGFR1, and EGFR only at much higher concentrations (IC50 = 0.14, 2.29, and >100 µM, respectively). Reported to selectively inhibit PDGFβ- over EGF-stimulated proliferation in EGFR-expressing NIH 3T3 cultures (IC50 = 0.11 and 21.9 µM, respectively) and exhibit much weaker potency against the proliferation of HUVEC cells upon FGF or VEGF stimulation (IC50 = 10 µM).
    产品目录编号 521237
    品牌系列 Calbiochem®
    同义词 (Z)-3-(2,4-Dimethyl-5-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl-6-phenyl)-1H-pyrrol-3-yl)-propionic acid, VEGFR Tyrosine Kinase Inhibitor XXXI, VEGFR2 Kinase Inhibitor XXIX
    参考
    参考 Sun, L., et al. 1999. J. Med. Chem. 42, 5120.
    产品信息
    CAS号 251356-45-3
    形式 Dark orange solid
    Hill配方 C₂₄H₂₂N₂O₃
    化学配方 C₂₄H₂₂N₂O₃
    Molar Mass 386.4
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC
    理化信息
    溶解度 DMSO
    安全信息
    S相 S: 22-24/25-36/37/39

    Do not breathe dust.
    Avoid contact with skin and eyes.
    Wear suitable protective clothing, gloves and eye/face protection.
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,521237,PDGFR Tyrosine Kinase Inhibitor VII - CAS 251356-45-3 - Calbiochem

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