merck millipore,默克密理愽
  • merck millipore,默克密理博,MABS45,Anti-Annexin A1 Antibody, clone CPTC-ANXA1-2

  • merck millipore,默克密理博,MABS45,Anti-Annexin A1 Antibody, clone CPTC-ANXA1-2

    产品名称：Anti-Annexin A1 Antibody, clone CPTC-ANXA1-2
    产品型号：MABS45
    This Anti-Annexin A1 Antibody, clone CPTC-ANXA1-2 is validated for use in WB, IH for the detection of Annexin A1.

    merck millipore,默克密理博,MABS45,Anti-Annexin A1 Antibody, clone CPTC-ANXA1-2

  • 产品介绍
  • merck millipore,默克密理博,MABS45,Anti-Annexin A1 Antibody, clone CPTC-ANXA1-2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIHC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABS45
    描述 Anti-Annexin A1 Antibody, clone CPTC-ANXA1-2
    Alternate Names
    • Chromobindin-9
    • annexin A1
    • chromobindin-9
    • annexin I (lipocortin I)
    • Lipocortin I
    • calpactin-2
    • Calpactin II
    • annexin-1
    • Phospholipase A2 inhibitory protein
    • Annexin I
    • Calpactin-2
    • Annexin-13
    背景信息 Annexin A1 (ANXA1) is a calcium and phospholipid binding protein almost entirely restricted to microglia in the CNS. During the peripheral inflammatory response, Annexin A1 is instrumental in the phagocytosis of apoptotic leukocytes. Annexin A1 restores the ability of microglia to differentiate between apoptotic and non-apoptotic cells during inflammatory activation. Current research is geared towards using Annexin A1 as a therapeutic target in neuroinflammation. Annexin A1 has also been shown to be influential in cancer development and proliferation.
    产品信息
    格式 Purified
    控制
    • K562 cell lysate
    演示 Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This Anti-Annexin A1 Antibody, clone CPTC-ANXA1-2 is validated for use in WB, IH for the detection of Annexin A1.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    应用说明 Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH.

    生物信息
    免疫原品种 Full length recombinant protein corresponding to human Annexin A1.

    Material obtained from the National Cancer Institute’s Clinical Proteomic Technologies for Cancer (CPTC) program
    克隆 CPTC-ANXA1-2
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG2aκ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_000691
    Entrez基因汇总 Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. [provided by RefSeq].
    基因符号
    • ANX1
    • p35
    • ANXA1
    • LPC1
    纯化方法 Protein G
    UniProt编号
    • P04083
    UniProt汇总 FUNCTION: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity.

    SUBUNIT STRUCTURE: Homodimer in placenta (20%); linked by transglutamylation. Interacts with DYSF (By similarity).

    SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). Cell projection › cilium (By similarity). Basolateral cell membrane (By similarity). Note: Found in the cilium, nucleus and basolateral cell membrane of ciliated cells in the tracheal endothelium (By similarity). Found in the cytoplasm of type II pneumocytes and alveolar macrophages (By similarity).

    DOMAIN: A pair of annexin repeats may form one binding site for calcium and phospholipid.

    PTM: Phosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in loss of the inhibitory activity.

    SEQUENCE SIMILARITIES: Belongs to the annexin family.

    Contains 4 annexin repeats.
    产品使用声明
    质量保证 Evaluated by Western Blot in K562 cell lysate.

    Western Blot Analysis: 0.5 µg/mL of this antibody detected Annexin A1 on 10 µg of K562 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABS45,Anti-Annexin A1 Antibody, clone CPTC-ANXA1-2

上一件merck millipore产品：merck millipore,默克密理博,AP194F,Donkey Anti-Chicken IgY Antibody, FITC conjugate, Species Adsorbed
下一件merck millipore产品：merck millipore,默克密理博,ABS511,Anti-Securin Antibody


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