merck millipore,默克密理愽
  • merck millipore,默克密理博,14-683,PAK3 Protein, active, 10 µg

  • merck millipore,默克密理博,14-683,PAK3 Protein, active, 10 µg

    产品名称：PAK3 Protein, active, 10 µg
    产品型号：14-683
    Active, C-terminal 6His-tagged, recombinant, human full length, PAK3. For use in Kinase Assays.

    merck millipore,默克密理博,14-683,PAK3 Protein, active, 10 µg

  • 产品介绍
  • merck millipore,默克密理博,14-683,PAK3 Protein, active, 10 µg

    描述
    产品目录编号 14-683
    品牌系列 Upstate
    商名
    • Upstate
    描述 PAK3 Protein, active, 10 µg
    概述 C-terminal 6His-tagged, recombinant, human full length, PAK3.

    mitosis
    应用
    应用 Active, C-terminal 6His-tagged, recombinant, human full length, PAK3. For use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 PAK3 expressed by baculovirus in Sf21 cells.
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_002578.2
    Entrez基因汇总 PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. A point mutation in this gene has been linked to nonsyndromic X-linked mental retardation.
    基因符号
    • bPAK
    • PAK3
    • oligophrenin-3
    • CDKN1A
    • OPHN3
    • PAK3beta
    • PAK-3
    • Beta-PAK
    • OTTHUMP00000062894
    • Oligophrenin-3
    • hPAK3
    • MRX47
    • MRX30
    蛋白靶 PAK3
    纯化方法 Ni2+/NTA-agarose
    靶子系列 STE
    UniProt编号
    • O75914
    UniProt汇总 FUNCTION: SwissProt: O75914 # Key regulator of synapse formation and plasticity in the hippocampus (By similarity).
    COFACTOR: Magnesium (By similarity).
    SIZE: 559 amino acids; 62310 Da
    SUBUNIT: Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Shows highly specific binding to the SH3 domains of phospholipase C-gamma and of adapter protein NCK.
    TISSUE SPECIFICITY: Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus.
    PTM: Autophosphorylated when activated by CDC42/p21.
    DISEASE: SwissProt: O75914 # Defects in PAK3 are the cause of non-syndromic mental retardation X-linked type 30 (MRX30) [MIM:300558]; also called X- linked mental retardation type 47 (MRX47). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs.
    SIMILARITY: SwissProt: O75914 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. & Contains 1 CRIB domain. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 routinely evaluated by phosphorylation of PAKtide (RRRLSFAEPG).
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C from date of shipment
    包装信息
    数量 10 µg

    merck millipore,默克密理博,14-683,PAK3 Protein, active, 10 µg

上一件merck millipore产品：merck millipore,默克密理博,05-639,Anti-14-3-3γ Antibody, clone CG31-2B6
下一件merck millipore产品：merck millipore,默克密理博,475981,Myosin Light Chain Kinase Inhibitor Peptide 18 - Calbiochem


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