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merck millipore,默克密理博,MABS19,Anti-Cytochrome P450 1A1 Antibody, clone 17D7.1
产品名称：Anti-Cytochrome P450 1A1 Antibody, clone 17D7.1
产品型号：MABS19
Anti-Cytochrome P450 1A1 Antibody, clone 17D7.1 is an antibody against Cytochrome P450 1A1 for use in WB, IH.
merck millipore,默克密理博,MABS19,Anti-Cytochrome P450 1A1 Antibody, clone 17D7.1
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H IHC, WB M Purified Monoclonal Antibody 描述 产品目录编号 MABS19 描述 Anti-Cytochrome P450 1A1 Antibody, clone 17D7.1 Alternate Names - Cytochrome P450-C
- cytochrome P450, family 1, subfamily A, polypeptide 1
- cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1
- flavoprotein-linked monooxygenase
- aryl hydrocarbon hydroxylase
- xenobiotic monooxygenase
- cytochrome P1-450, dioxin-inducible
- Cytochrome P450-P1
- cytochrome P450 1A1
- Cytochrome P450 form 6
背景信息 Cytochrome P450 1A1 (CYP1A1) encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme’s endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. 产品信息 格式 Purified 控制 - Human liver tissue lysate
演示 Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide. 应用 应用 Anti-Cytochrome P450 1A1 Antibody, clone 17D7.1 is an antibody against Cytochrome P450 1A1 for use in WB, IH. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis: 1:400 dilution from a previous lot detected Cytochrome P450 1A1 in rat lung tissue. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human Cytochrome P450 1A1. 克隆 17D7.1 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgMκ 品种反应性 RatHuman Species Reactivity Note Demonstrated to react with human and rat. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_000490
Entrez基因汇总 This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. [provided by RefSeq]. 基因符号 - CYP1A1
- CYP1
- CP11
- P1-450
- P450-C
- P450DX
- AHH
- AHRR
- CYPIA
纯化方法 Ion Exchange UniProt编号 - P04798
UniProt汇总 FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
CATALYTIC ACTIVITY: RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
COFACTOR: Heme group (By similarity).
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
TISSUE SPECIFICITY: Lung, lymphocytes and placenta.
INDUCTION: By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
SEQUENCE SIMILARITIES: Belongs to the cytochrome P450 family.产品使用声明 质量保证 Evaluated by Western Blot in human liver tissue lysate.
Western Blot Analysis: 2 µg/mL of this antibody detected Cytochrome P450 1A1 on 10 µg of human liver tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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