merck millipore,默克密理愽
  • merck millipore,默克密理博,07-1735,Anti-HuR Antibody

  • merck millipore,默克密理博,07-1735,Anti-HuR Antibody

    产品名称：Anti-HuR Antibody
    产品型号：07-1735
    Use Anti-HuR Antibody (Rabbit Polyclonal Antibody) validated in WB, IF to detect HuR also known as ELAV-like 1, Hu antigen R.

    merck millipore,默克密理博,07-1735,Anti-HuR Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-1735,Anti-HuR Antibody

    Replacement Information
    Replacement Information 07-1735 is recommended replacement for AB5831.

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, R, HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-1735
    Replaces AB5831
    描述 Anti-HuR Antibody
    Alternate Names
    • embryonic lethal, abnormal vision, drosophila, homolog-like 1
    • ELAV-like 1
    • Hu antigen R
    • Hu-antigen R
    • embryonic lethal
    • abnormal vision
    • drosophila
    背景信息 HuR (Hu-antigen R, ELAV-like protein 1, ELAV1) is an RNA bindnig protein that contains 3 RNA-binding domains. It is known to binds AU-rich elements if mRNA. It regulates gene expression by destabilizing their mRNA. It is known to be upregulated in certain cancers such as breast and gastric cancers. Some of its targets include cFos, IL-3, and BRCA1 mRNAs. HuR has also been shown to be involved in the regulation of VEFG-A and NFkB expression in certain cell types. It activation and accumulation are also linked to many energy signaling molcules such as that of the PI3K/Akt pathway and AMPK.
    产品信息
    格式 Affinity Purified
    控制
    • Jurkat cell lysate
    演示 Rabbit polyclonal precipitated antibody in a solution of 50% saturated ammonium sulfate and PBS containing no preservatives
    应用
    应用 Use Anti-HuR Antibody (Rabbit Polyclonal Antibody) validated in WB, IF to detect HuR also known as ELAV-like 1, Hu antigen R.
    主要应用
    • Western Blotting
    应用说明 Immunofluorescent ICC Analysis:
    生物信息
    免疫原品种 Synthetic peptide corresponding to the N-terminus of human HuR.
    表位 N-terminus
    宿主 Rabbit
    特异性 Detects HuR
    品种反应性 MouseRatHuman
    Species Reactivity Note Human, Mouse, Rat. Other species have not been tested.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_001410.2
    Entrez基因汇总 The protein encoded by this gene is a member of the ELAVL protein family. This encoded protein contains 3 RNA-binding domains and binds cis-acting AU-rich elements. It destabilizes mRNAs and thereby regulates gene expression. [provided by RefSeq]
    基因符号
    • MelG
    • ELAV1
    • HUR
    • HuR
    • Hua
    纯化方法 Affinity purified polyclonal precipitated in ammonium sulfate.
    UniProt编号
    • Q15717
    UniProt汇总 FUNCTION: SwissProt: Q15717 # Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs.
    SIZE: 326 amino acids; 36092 Da
    SUBUNIT: Interacts with ANP32A.
    TISSUE SPECIFICITY: Ubiquitous.
    PTM: Methylated at Arg-217 by CARM1 in macrophages in response to LPS challenge.
    SIMILARITY: SwissProt: Q15717 ## Belongs to the RRM elav family. & Contains 3 RRM (RNA recognition motif) domains.
    产品使用声明
    质量保证 Western Blot Analysis:
    The antibody detected HuR at 1:500-1:1,000 dilutions in Jurkat cell lysate resolved via SDS-PAGE and transferred to PVDF.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20°C from date of receipt.
    Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,07-1735,Anti-HuR Antibody

上一件merck millipore产品：merck millipore,默克密理博,SF-1982,CSMD3; Human, Cyanine 5 RNA Detection Probe,SmartFlare
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