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品种反应性 主要应用 宿主 格式 抗体类型 R WB, IHC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB9828-50UL 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Kv11.2 Antibody Alternate Names - erg2, KCNH6, ether-a-go-go channel 2, Voltage-gated K<sup>+</sup> channel subfamily H member 6
- erg2
- KCNH6
- ether-a-go-go channel 2
产品信息 格式 Affinity Purified 控制 - Included free of charge with the antibody is 40 μg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 μL of sterile deionized water. For negative control, preincubate 1 μg of peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
演示 Affinity purified immunoglobulin. Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.025% sodium azide as a preservative. Reconstitute with 50 μL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min). 应用 应用 Anti-Kv11.2 Antibody is an antibody against Kv11.2 for use in IH & WB. 主要应用 - Western Blotting
- Immunohistochemistry
应用说明 Western blot: 1:200 using ECL on rat brain lysate and rat cortex lysate.
Immunohistochemistry on rat brain sections.
Dilutions should be made using a carrier protein such as BSA (1-3%).
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Purified peptide from amino acids 185-198 of human Kv11. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes Kv11.2 (erg2, Voltage-gated K+ channel subfamily H member 6, KCNH6, ether-a-go-go channel 2). 同种型 IgG 品种反应性 Rat Species Reactivity Note The immunogen sequence is identical in chicken and 13 of 14 amino acids identical in mouse. 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_173092.1
- NM_030779.2
Entrez基因汇总 Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. 基因符号 - Kv11.2
- KCNH6
- erg2
- ERG2
- HERG2
UniProt编号 - Q9H252
UniProt汇总 FUNCTION: SwissProt: Q9H252 # Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current (By similarity). Channel properties may be modulated by cAMP and subunit assembly.
SIZE: 994 amino acids; 109925 Da
SUBUNIT: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimers with KCNH2/ERG1 and KCNH7/ERG3 (By similarity).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed in prolactin-secreting adenomas.
DOMAIN:SwissProt: Q9H252 The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
SIMILARITY: Belongs to the potassium channel family. H (Eag) subfamily. & Contains 1 cyclic nucleotide-binding domain. & Contains 1 PAC (PAS-associated C-terminal) domain. & Contains 1 PAS (PER-ARNT-SIM) domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 50 µL
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