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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB M Purified Monoclonal Antibody 描述 产品目录编号 MABS151 描述 Anti-PFK Antibody, clone 16H1.1 Alternate Names - Phosphohexokinase
- 6-phosphofructokinase, muscle type
- Phosphofructo-1-kinase isozyme A
- PFK-A
- Phosphofructokinase-M
- Phosphofructokinase 1
背景信息 Phosphofructokinase 1 (PFK) is a metabolic enzyme that is highly expressed in muscle cells. PFK catalyzes the phosphorylation of fructose-6-phosphate to form fructose-1,6-biphosphate, the main substrate that initiates the glycolytic pathway. The active PFK enzyme is a tetramer formed from pre-existing dimers, and is primarily activated by fructose-2,6-bisphosphate. However, several endogenous molecules such as ATP, ADP, AMP, lactate, citrate, actin, and microtubules regulate PFK activity by stabilizing either the dimer or tetramer conformation. PFK is also phosphorylated at multiple serine, threonine and tyrosine residues in response to insulin, serotonin, and epinephrine, which triggers glycolysis. Defects in PFK may result in Tarui disease. 产品信息 格式 Purified 控制 - Human heart tissue lysate
演示 Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-PFK Antibody, clone 16H1.1 is an antibody against PFK for use in Western Blotting. 主要应用 - Western Blotting
应用说明 Western Blot Analysis: 0.5 - 2 µg/mL from a representative lot detected PFK in 10 µg of rat and mouse heart tissue lysates. 生物信息 免疫原品种 GST-tagged recombinant protein corresponding to human PFK. 克隆 16H1.1 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG2bκ 品种反应性 RatHumanMouse Species Reactivity Note Demonstrated to react with Human, Mouse, and Rat. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_000280
基因符号 - PFKX
- PFKM
纯化方法 Protein G purified UniProt编号 - P08237
产品使用声明 质量保证 Evaluated by Western Blot in human heart tissue lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected PFK in 10 µg of human heart tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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