- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, M WB M Purified Monoclonal Antibody 描述 产品目录编号 MABS15 Replaces 06-506 描述 Anti-IRS-2 Antibody, clone 9.5.2 Alternate Names - insulin receptor substrate 2
背景信息 Insulin receptor substrate (IRS) molecules are key mediators in insulin signaling and play a central role in maintaining basic cellular functions such as growth, survival, and metabolism. They act as docking proteins between the insulin receptor and a complex network of intracellular signaling molecules containing Src homology 2 (SH2) domains. Four members (IRS-1, IRS-2, IRS-3, IRS-4) of this family have been identified that differ as to tissue distribution, subcellular localization, developmental expression, binding to the insulin receptor, and interaction with SH2 domain-containing proteins. In fact, IRS-1 appears to have its major role in skeletal muscle whereas IRS-2 appears to regulate hepatic insulin action as well as pancreatic beta cell development and survival. By contrast, IRS-3 and IRS-4 genes appear to play a redundant role in the IRS signaling system. Defects in muscle IRS-1 expression and function have been reported in insulin-resistant states such as obesity and type 2 diabetes. 产品信息 格式 Purified 控制 - Insulin treated CHO IR/IRS-2 cell lysate
演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. 应用 应用 Anti-IRS-2 Antibody, clone 9.5.2 detects level of IRS-2 & has been published & validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to mouse IRS-2. 表位 Unknown 克隆 9.5.2 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This antibody recognizes IRS-2. 同种型 IgG1κ 品种反应性 RatMouse Species Reactivity Note Demonstrated to react with mouse. Predicted to react with rat based on 100% sequence homology. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_001074681.1
基因符号 - IRS-2
- IRS2
纯化方法 Protein G purfied UniProt编号 - P81122
UniProt汇总 FUNCTION: May mediate the control of various cellular processes by insulin.
TISSUE SPECIFICITY: Skeletal muscle, lung, brain, liver, kidney, heart and spleen.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR by similarity.
SEQUENCE SIMILARITIES: Contains 1 IRS-type PTB domain.
Contains 1 PH domain.产品使用声明 质量保证 Evaluated by Western Blot in Insulin treated CHO IR/IRS-2 cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected IRS-2 on 10 µg of Insulin treated CHO IR/IRS-2 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,250233,Cytochalasin B, Helminthosporium dematioideum - CAS 14930-96-2 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,ABT132,Anti-Profilin-1 Antibody
相关产品
merck millipore,默克密理博,217590,Anti-CD40 Mouse mAb (EA-5)
merck millipore,默克密理博,2610-OP,OmniPur N,N'-Methylene Bis Acrylamide - CAS 110-26-9 - Calbiochem
merck millipore,默克密理博,NS400,α-Synuclein ELISA Kit
merck millipore,默克密理博,SF-1290,Albumin; Human, Cyanine 5 RNA Detection Probe,SmartFlare
merck millipore,默克密理博,ABT132,Anti-Profilin-1 Antibody
merck millipore,默克密理博,218757,Caspase-6 Inhibitor I - Calbiochem
merck millipore,默克密理博,71504,D-Tube™ Dialyzer Mini, MWCO 6-8 kDa
merck millipore,默克密理博,HTS157M,ChemiSCREEN™ Human α2B Adrenergic Receptor Membrane Preparation
merck millipore,默克密理博,16-157,Protein A Agarose/Salmon Sperm DNA, 2.5 mL