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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M ICC, WB Rb Purified Polyclonal Antibody 描述 产品目录编号 ABT132 描述 Anti-Profilin-1 Antibody Alternate Names - Profilin 1
- Profilin-1
背景信息 Profilin-1 (PFN1) is a small cytoplasmic protein that regulates actin polymerization in response to various extracellular signals. It may bind G-actin preventing actin assembly, which is released upon stimulation with phosphatidylinositol 4,5-bisphosphate. At low concentrations, Profilin-1 may also facilitate nucleotide exchange required for elongation of actin filaments. Profilin-1 also interacts with polyproline-containing proteins, such as the Huntingtin protein, to inhibit protein aggregation. Profilin-1 is regulated by phosphorylation of its Ser137 residue by ROCK, and dephosphorylation by the protein phosphatase 1. In normal cells, Profilin-1 may be involved in cell adhesion, cytokinesis, cell motility, vesicle formation, and neuron migration. It is also associated with neurodegenerative diseases and cancer. 产品信息 格式 Purified 控制 - HeLa cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 This Anti-Profilin-1 Antibody is validated for use in Western Blotting, ICC for the detection of Profilin-1. 主要应用 - Immunocytochemistry
- Western Blotting
应用说明 Western Blot Analysis: 0.5 µg/mL from a representative lot detected Profilin-1 in 10 µg of Jurkat and C2C12 cell lysates, rat kidney and human kidney tissue lysates.
Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected Profilin-1 in HeLa, C2C12, and A431 cells.生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human Profilin-1. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 RatHumanMouse Species Reactivity Note Demonstrated to react with Human, Mouse, and Rat. Predicted to react with Canine, Hamster, Rhesus Macaque, Giant Panda, and Chimpanzee based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_005013
基因符号 - PFN1
纯化方法 Protein A purified UniProt编号 - P07737
产品使用声明 质量保证 Evaluated by Western Blot in HeLa cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected Profilin-1 on 10 µg of HeLa cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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