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merck millipore,默克密理博,MABN641,Anti-TMEM16B Antibody, clone 7H10
产品名称：Anti-TMEM16B Antibody, clone 7H10
产品型号：MABN641
Anti-TMEM16B Antibody, clone 7H10 is a highly specific mouse monoclonal antibody, that targets TMEM16B & has been tested in IHC, western blotting & ICC.
merck millipore,默克密理博,MABN641,Anti-TMEM16B Antibody, clone 7H10
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H, M ICC, IHC, WB M Purified Monoclonal Antibody 描述 产品目录编号 MABN641 描述 Anti-TMEM16B Antibody, clone 7H10 Alternate Names - Transmembrane protein 16B
- Anoctamin-2
背景信息 The protein named Anoctamin-2 or alternatively Transmembrane protein 16B and encoded by the human gene ANO2/C12orf3/TMEM16B is a calcium activated chloride channel that plays a role in smell or olfactory signal transduction and photoreception. Odorant molecules bind to odor-sensing receptors leading to an increase in calcium entry that then activates TMEM16B calcium current which amplifies the depolarization of the Odor-sensing receptors. TEMEM16B also mediates light perception amplification in the retina where TMEM16B is a component of the presynaptic protein complex recruited to specialized plasma membrane domains of photoreceptors. TEMEM16B is expressed in sensory neurons particularly in the retina and olfactory neurons; it localizes to the plasma membrane where it is a multi-pass membrane bound protein. TEMEM16B has multiple isoforms and recent research suggest that the native channel may be composed of two or more splicing isoforms acting as subunits that together shape the channel properties. 产品信息 格式 Purified 演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-TMEM16B Antibody, clone 7H10 is a highly specific mouse monoclonal antibody, that targets TMEM16B & has been tested in IHC, western blotting & ICC. 主要应用 - Immunocytochemistry
- Immunohistochemistry
- Western Blotting
应用说明 Western Blotting Analysis: A representative lot detected TMEM16B in 293-EBNA cell lysates overexpressing TMEM16B and in mouse retina and brain homogenates (Stohr, H., et al. (2009). The Journal of Neuro. 29(21):6809-6818).
Immunocytochemistry Analysis: A representative lot detected TMEM16B in mouse retina cells (Stohr, H., et al. (2009). The Journal of Neuro. 29(21):6809-6818).生物信息 免疫原品种 GST-tagged recombinant protein corresponding to the N-terminus of human TMEM16B. 表位 N-terminus 克隆 7H10 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG1κ 品种反应性 HumanMouse 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_065106
基因符号 - TMEM16B
- ANO2
- C12orf3
纯化方法 Protein G purified UniProt编号 - Q9NQ90
产品使用声明 质量保证 Evaluated by Immunohistochemistry in mouse retina tissue.
Imunnohistochemistry Analysis: A 1:50 dilution of this antibody detected TMEM16B in mouse retina tissue.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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