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品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABF248 描述 Anti-C5AR Antibody1 Alternate Names - C5AR1
- C5a anaphylatoxin chemotactic receptor
- C5a-R
- C5aR
- CD88
背景信息 The protein named C5a anaphylatoxin chemotactic receptor (C5a-R/C5aR), CRAR1 complement component 5a receptor1, or CD88 and encoded by the human gene C5AR1/C5AR/C5R1 is a plasma membrane bound receptor for the inflammatory peptide anaphylatoxin C5a. Host defense and inflammatory responses are controlled and amplified by receptor-mediated events often initiated by chemotactic factors that direct the approach of phagocytic cells. Complement receptors CR1 and CR3 are responsible for the phagocytic and adhesive properties of neutrophils, whereas the C5a receptor, C5AR1, mediates the pro-inflammatory and chemotactic actions of the complement anaphylatoxin C5a on immune and other cells, which in turn mediates granule enzyme release, chemotaxis, and superoxide production by these cells. C5AR1 is part of the G-protein coupled receptor 1 family of proteins and is known to be expressed on granulocytes, monocytes, dendritic cells, astrocytes, microglia and the liver immortalized line, HepG2 and the immortalized cell line HL-60. In addition to stimulating chemotaxis, granule enzyme release and superoxide anion production, this receptor stimulates an increase in the expression and activity of the adhesion molecule MAC-1, and CR1, and a decrease in cell-surface glycoprotein 100MEL-14 on neutrophils. In vivo, C5AR1 appears to participate in anaphylactoid and septic shock as well. 产品信息 格式 Affinity Purified 演示 Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide and 50% glycerol. 应用 应用 Anti-C5AR Antibody1 is a highly specific rabbit polyclonal antibody, that targets C5AR & has been tested in western blotting, IHC & Immunofluorescence. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected C5AR1 in human liver tissue.
Immunofluorescence Analysis: A 1:25 dilution from a representative lot detected C5AR1 in HepG2 cells.生物信息 免疫原品种 GST-tagged fusion protein corresponding to human C5AR1. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 Human 抗体类型 Polyclonal Antibody 基因符号 - C5R1
- C5AR1
- C5AR
纯化方法 Antigen Affinity purified UniProt编号 - P21730
产品使用声明 质量保证 Evaluated by Western Blotting in PC3 cell lysate.
Western Blotting Analysis: A 1:800 dilution of this antibody detected C5AR1 in PC3 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.包装信息 数量 150 µL
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