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merck millipore,默克密理博,MABN53,Anti-Dopamine D2 receptor (DRD2) Antibody, clone 3D9
产品名称：Anti-Dopamine D2 receptor (DRD2) Antibody, clone 3D9
产品型号：MABN53
This Anti-Dopamine D2 receptor (DRD2) Antibody, clone 3D9 is validated for use in WB, IC for the detection of Dopamine D2 receptor (DRD2).
merck millipore,默克密理博,MABN53,Anti-Dopamine D2 receptor (DRD2) Antibody, clone 3D9
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H, R ICC, WB M Purified Monoclonal Antibody 描述 产品目录编号 MABN53 描述 Anti-Dopamine D2 receptor (DRD2) Antibody, clone 3D9 Alternate Names - Dopamine D2 receptor
背景信息 Problems in the CNS dopaminergic system are thought to be the root cause of some neuropsychiatric disorders. Dopamine D2 receptor is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Dopamine D2 receptor signaling using Nurr1 and ERK may play an important role in mesencephalic dopaminergic neuronal development. Faulty D2 receptors have been common in cases of ROS-dependent hypertension. In addition, defects in DRD2 are associted with alcohol-responsive dystonia, varying susceptability to familial alcoholism as well as a contributing factor to the suicide risk in alcoholics. 产品信息 格式 Purified 控制 - Rat spinal cord tissue lysate
演示 Purified mouse monoclonal IgMκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 This Anti-Dopamine D2 receptor (DRD2) Antibody, clone 3D9 is validated for use in WB, IC for the detection of Dopamine D2 receptor (DRD2). 主要应用 - Immunocytochemistry
- Western Blotting
应用说明 Immunocytochemistry Analysis: A previous lot was used by an independent laboratory to detect Dopamine D2 receptor in Ntera-2 cells and in rat brain neurons. Courtesy of Glenn Morris, Wolfson Centre for Inherited Neuromuscular Disease. 生物信息 免疫原品种 Linear peptide corresponding to human Dopamine D2 receptor. 克隆 3D9 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgMκ 品种反应性 HumanRat Species Reactivity Note Demonstrated to react with rat. Predicted to react with human based on immunogen design. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_000786
Entrez基因汇总 This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq]. 基因符号 - D2R
- DRD2
- D2DR
纯化方法 CHT Ion exchange UniProt编号 - P14416
UniProt汇总 FUNCTION: This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
SIZE: 443 amino acids; 50619 Da
SUBUNIT: Interacts with GPRASP1, neurabin-2 and CLIC6 (By similarity). Interacts with CADPS and CADPS2.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
DISEASE: It has been suggested that DRD2 is involved in psychiatric disorders; especially in schizophrenia. & Defects in DRD2 are associated with myoclonus dystonia (MD) [MIM:159900]; also known as myoclonic dystonia, alcohol- responsive dystonia and dystonia-11 (DYT11). MD is a movement disorder characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.产品使用声明 质量保证 Evaluated by Western Blot in rat spinal cord tissue lysate.
Western Blot Analysis: 5 µg/mL of this antibody detected Dopamine D2 receptor on 10 µg of rat spinal cord tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 200 µg
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