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merck millipore,默克密理博,MABN511,Anti-SUR2B Antibody, clone N323A/31
产品名称:Anti-SUR2B Antibody, clone N323A/31
产品型号:MABN511
Anti-SUR2B Antibody, clone N323A/31 is a highly specific mouse monoclonal antibody, that targets SUR & has been tested in western blotting & IHC.
merck millipore,默克密理博,MABN511,Anti-SUR2B Antibody, clone N323A/31
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M IHC, WB M Purified Monoclonal Antibody 描述 产品目录编号 MABN511 描述 Anti-SUR2B Antibody, clone N323A/31 Alternate Names - Sulfonylurea receptor 2
- ATP-binding cassette sub-family C member 9
背景信息 Sulfonylurea receptor 2 (Sur2), also known as ATP-binding cassette sub-family C member 9 (ABCC9), belongs to the ATP-binding cassette transporter (ABC transporter) superfamily. Sur2 is a subunit of ATP-sensitive potassium channels (KATP). The potassium channel, inwardly rectifying subfamily J member 11 (KCNJ11) interacts with Sur2 in the formation of cardiac and smooth muscle-type KATP channels, where Sur2 is required for activation and regulation of the channel. Sur2 is expressed at high levels in heart, skeletal muscle and ovary, and at moderate levels in brain, tongue and pancreatic islets. Expression in other tissue is at low levels. Defects in KCNJ11 are the cause of familial hyperinsulinemic hypoglycemia type 2 (HHF2), diabetes mellitus permanent neonatal (PNDM), as well as transient neonatal diabetes mellitus type 3 (TNDM3). Sur2B is an alternatively spliced isoforms of Sur2 (Sur2A), having differences in the amino acid sequence (1504-1545). 产品信息 格式 Purified 控制 - Human kidney tissue lysate
演示 Purified mouse monoclonal IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-SUR2B Antibody, clone N323A/31 is a highly specific mouse monoclonal antibody, that targets SUR & has been tested in western blotting & IHC. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Western Blotting Analysis: 1 µg/mL from a representative lot detected the cleaved form of SUR2B in mouse brain tissue lysate.
Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected the cleaved form of SUR2B in rat skeletal muscle tissue.
Western Blotting Analysis: A representative lot detected SUR2B in wild type mouse heart tissue lysate, and demonstrated a loss of signal in SUR2B knock out mouse heart tissue lysate (Prof. J. Trimmer, University of California, Davis.).生物信息 免疫原品种 Recombinant protein corresponding to the cytoplasmic domain of the cleaved form of rat SUR2. 表位 Cytoplasmic domain 克隆 N323/A31 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This antibody recognizes the cytoplasmic domain of the cleaved form of SUR2B. This antibody may cross react with SUR1 based upon 75% sequence homology. 同种型 IgG1 品种反应性 RatHumanMouse 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_037172
基因符号 - Sur2
- Abcc9
纯化方法 Protein G purified UniProt编号 - Q63563-2
产品使用声明 质量保证 Evaluated by Western Blotting in human kidney tissue lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected the cleaved form of SUR2B in 10 µg of human kidney tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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