merck millipore,默克密理愽
  • merck millipore,默克密理博,MABN446,Anti-RAB27A Antibody, clone 16H2.1

  • merck millipore,默克密理博,MABN446,Anti-RAB27A Antibody, clone 16H2.1

    产品名称：Anti-RAB27A Antibody, clone 16H2.1
    产品型号：MABN446
    Anti-RAB27A Antibody, clone 16H2.1 is a highly specific mouse monoclonal antibody, that targets Ras related protein Rab-27A & has been tested in western blotting & IHC (Paraffin).

    merck millipore,默克密理博,MABN446,Anti-RAB27A Antibody, clone 16H2.1

  • 产品介绍
  • merck millipore,默克密理博,MABN446,Anti-RAB27A Antibody, clone 16H2.1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABN446
    描述 Anti-RAB27A Antibody, clone 16H2.1
    Alternate Names
    • GTP-binding protein Ram
    • Ras related protein Rab-27A
    • Rab-27
    背景信息 RAB27A, also known as Rab-27 or GTP-binding protein Ram, and encoded by the gene RAB27A/RAB27, plays a role in cytotoxic granule exocytosis in lymphocytes. RAB27A is required for both granule maturation and granule docking and priming at the immunologic synapse. Additionally, RAB27A binds SYTL1, SLAC2B, MYRIP, SYTL3, SYTL4 and SYTL5, and it interacts with RPH3A and RPH3A as well as MLPH and SYTL2. RAB27A is localized to the membrane bound in lipid-anchors, and it is also found in melanosomes and lysosomes and localizes to endosomal exocytic vesicles. RAB27A is expressed in all tissues examined except in brain. Low expression is found in thymus, kidney, muscle and placenta. RAB27A is detected in melanocytes, and in most tumor cell lines examined. RAB27A is expressed in cytotoxic T-lymphocytes (CTL) and mast cells. Defects in RAB27A may be associated with Griscelli syndrome 2 a rare autosomal recessive disorder that results in pigmentary dilution of the skin and hair, the presence of large clumps of pigment in hair shafts, and an accumulation of melanosomes in melanocytes. GS2 patients also develop an uncontrolled T-lymphocyte and macrophage activation syndrome, known as hemophagocytic syndrome, leading to death in the absence of bone marrow transplantation. Neurological impairment is present in some patients, likely as a result of hemophagocytic syndrome.
    产品信息
    格式 Purified
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-RAB27A Antibody, clone 16H2.1 is a highly specific mouse monoclonal antibody, that targets Ras related protein Rab-27A & has been tested in western blotting & IHC (Paraffin).
    主要应用
    • Western Blotting
    应用说明 Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected RAB27A in human tonsil tissue.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human RAB27A.
    克隆 16H2.1
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG1κ
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_004571
    基因符号
    • RAB27
    • RAB27A
    纯化方法 Protein G purified
    UniProt编号
    • P51159
    产品使用声明
    质量保证 Evaluated by Western Blotting in SK-MEL-28 cell lysate.

    Western Blotting Analysis: 0.2 µg/mL of this antibody detected RAB27A in 10 µg of SK-MEL-28 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABN446,Anti-RAB27A Antibody, clone 16H2.1

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