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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M ICC, WB M Purified Monoclonal Antibody 描述 产品目录编号 MABN42 描述 Anti-Neuregulin-1 Antibody, clone D11 Alternate Names - glial growth factor
- neuregulin 1
- sensory and motor neuron derived factor
- neu differentiation factor
- pro-neuregulin-1, membrane-bound isoform
- heregulin, alpha (45kD, ERBB2 p185-activator)
背景信息 The group of Neuregulin-1 proteins are cell-cell signaling molecules and are ligands for receptor tyrosine kinases of the ErbB/HER subfamily. Type III NRG1 proteins (also referred to as CRD-NRG1 proteins) play a critical role in neural development, including myelination, motor and sensory neuron survival, and neuromuscular synapse development (Falls, 2003). Defects in animals lacking type III NRGs include retraction of nerve terminals from newly formed synapses, absence of Schwann cells from peripheral nerves, and loss of motor and sensory neurons (Wolpowitz et al., 2000). Available evidence indicates that most Type III NRG1 proteins are synthesized as transmembrane proteins with 2 TM domains, and that proteolytic processing produces a bioactive transmembrane form (NTFm) which serves as a juxtacrine signal (Wang, 2001; Falls, 2003). 产品信息 格式 Purified 控制 - Mouse brain microsomal tissue lysate
演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect Neuregulin-1 using this Anti-Neuregulin-1 Antibody, clone D11 validated for use in WB & IC. 主要应用 - Immunocytochemistry
- Western Blotting
应用说明 Immunocytochemistry Analysis: A previous lot of this antibody was used successfully by an independent laboratory in IC. (Pirotte, D., et al.) 生物信息 免疫原品种 His-tagged recombinant protein corresponding to mouse Neuregulin-1 at the extracellular domain. 表位 Extracellular domain 克隆 D11 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This antibody recognizes Neuregulin-1 at the extracellular domain. 同种型 IgG1κ 品种反应性 Mouse Species Reactivity Note Demonstrated to react with mouse. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_848706
基因符号 - Pro-NRG1
- GGF
- NDF
- GGF2
- HGL
- MST131
- HRGA
- HRG
- HRG1
- SMDF
- ARIA
- pro-NRG1
- MSTP131
纯化方法 Protein G UniProt编号 - Q6DR99
产品使用声明 质量保证 Evaluated by Western Blot in mouse brain microsomal tissue lysate.
Western Blot Analysis: 0.25 µg/mL of this antibody detected Neuregulin-1 on 10 µg of mouse brain microsomal tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,MABT213,Anti-SHP-1 Antibody, clone HG213, rabbit monoclonal
下一件merck millipore产品：merck millipore,默克密理博,07-2046,Anti-EHMT1 Antibody
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