merck millipore,默克密理博,MABN1089,Anti-Pyruvate Carboxylase, clone EPR7365, Rabbit Monoclonal Antibody

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merck millipore,默克密理博,MABN1089,Anti-Pyruvate Carboxylase, clone EPR7365, Rabbit Monoclonal Antibody
产品名称：Anti-Pyruvate Carboxylase, clone EPR7365, Rabbit Monoclonal Antibody
产品型号：MABN1089
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target.

merck millipore,默克密理博,MABN1089,Anti-Pyruvate Carboxylase, clone EPR7365, Rabbit Monoclonal Antibody

产品介绍

merck millipore,默克密理博,MABN1089,Anti-Pyruvate Carboxylase, clone EPR7365, Rabbit Monoclonal Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	WB	Rb	Unpurified	Monoclonal Antibody

描述
产品目录编号	MABN1089
描述	Anti-Pyruvate Carboxylase, clone EPR7365, Rabbit Monoclonal Antibody
Alternate Names	PCB Pyruvate carboxylase mitochondrial Pyruvic carboxylase
背景信息	Pyruvate carboxylase (PC), also known as mitochondrial, or Pyruvic carboxylase (PCB), is the enzyme that catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second reaction. Pyruvate Carboxylase catalyzes in a tissue specific manner. The initial reactions are primarily done in the liver and kidney, while second (lipid synthesis from pyruvate) being more concerned with lipid metabolism are more focused in adipose tissue, liver, and brain. PC is an essential part of the Krebs Cycle in mitochondria and Pyruvate Carboxylase plays a crucial role in gluconeogenesis, lipogenesis, in the biosynthesis of neurotransmitters, and in glucose-induced insulin secretion by pancreatic islets. Oxaloacetate produced by Pyruvate Carboxylase is an important intermediate, which is used in many biosynthetic pathways as well. Because PC serves in a few important metabolic crossroads between lipid and carbohydrate metabolism, Pyruvate Carboxylase expression is highly regulated and responsive to metabolic conditions. Therefore, Pyruvate Carboxylase is a target for research in metabolic syndrome and diabetes. Defects in Pyruvate Carboxylase can cause lactic acidosis and hypoglycemia.

产品信息
格式	Unpurified
演示	Rabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target.
主要应用	Western Blotting
应用说明	Produced in collaboration with Epitomics™

生物信息
免疫原品种	Synthetic peptide corresponding to human Pyruvate Carboxylase.
克隆	EPR7365
浓缩	Please refer to lot specific datasheet.
宿主	Rabbit
同种型	IgG
品种反应性	Human
Species Reactivity Note	Human
抗体类型	Monoclonal Antibody
基因符号	PC
纯化方法	Unpurified
UniProt编号	P11498

产品使用声明
质量保证	Evaluated by Western Blotting in human fetal liver, fetal kidney, and HepG2 lysates. Western Blotting Analysis: A 1:1,000-10,000 dilution of this antibody detected Pyruvate Carboxylase in human fetal liver, fetal kidney, and HepG2 lysates.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.