merck millipore,默克密理博,MABN1037,Anti-ROCK2 Antibody, clone EPR7141(B), rabbit monoclonal

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merck millipore,默克密理博,MABN1037,Anti-ROCK2 Antibody, clone EPR7141(B), rabbit monoclonal
产品名称：Anti-ROCK2 Antibody, clone EPR7141(B), rabbit monoclonal
产品型号：MABN1037
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target.

merck millipore,默克密理博,MABN1037,Anti-ROCK2 Antibody, clone EPR7141(B), rabbit monoclonal

产品介绍

merck millipore,默克密理博,MABN1037,Anti-ROCK2 Antibody, clone EPR7141(B), rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
R, H	IHC, WB	Rb	Unpurified	Monoclonal Antibody

描述
产品目录编号	MABN1037
描述	Anti-ROCK2 Antibody, clone EPR7141(B), rabbit monoclonal
Alternate Names	p164 ROCK-2 Rho-associated protein kinase 2 Rho kinase 2 Rho-associated, coiled-coil-containing protein kinase 2 Rho-associated, coiled-coil-containing protein kinase II ROCK-II
背景信息	Rho-associated protein kinase 2 (ROCK2), also known as Rho kinase 2, Rho-associated, coiled-coil-containing protein kinase II, and p164 ROCK-2, is a member of the AGC serine/threonine protein kinase family. ROCK2 is a key regulator of actin cytoskeleton and cell polarity. It is involved in regulation of actin cytoskeleton organization, smooth muscle contraction, malignant cell transformation, tumor invasion and metastasis, stress fiber and focal adhesion formation, neurite retraction, motility and cell adhesion. Many of the key roles of ROCK2 are attributed to its ability to phosphorylate ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A, VIM, SORL1 and IRF4. ROCK2 regulates positively the activation of p42/MAPK1-p44/MAPK3 and the regulation of p90RSK/RPS6KA1 during myogenic differentiation. Alternatively, ROCK2 is a negative regulator of VEGF-induced angiogenic endothelial cell activation. Recent studies have shown that ROCK2 inhibits keratinocyte terminal differentiation and may play an important role in the timely initiation of centrosome duplication. It also may regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Additional evidence suggests that ROCK2 plays a critical role in the regulation of spine and synaptic properties in the hippocampus.

产品信息
格式	Unpurified
演示	Rabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target.
主要应用	Immunohistochemistry Western Blotting
应用说明	Immunohistochemistry Analysis: A 1:50-100 dilution from a representative lot detected ROCK2 in kidney tissue. Optimal working dilutions must be determined by end user.

生物信息
免疫原品种	Synthetic peptide corresponding to the C-terminus of human ROCK2.
表位	C-terminus
克隆	EPR7141(B)
宿主	Rabbit
品种反应性	RatHuman
抗体类型	Monoclonal Antibody
基因符号	KIAA0619 ROCK2
纯化方法	Unpurified
UniProt编号	O75116

产品使用声明
质量保证	Evaluated by Western Blotting in HeLa, L6, and A673 cell lysates. Western Blotting Analysis: A 1:10,000-50,000 dilution of this antibody detected ROCK2 in HeLa, L6, and A673 cell lysates.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.