merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB4709,Anti-Caspase 9 Antibody, clone 2-23

  • merck millipore,默克密理博,MAB4709,Anti-Caspase 9 Antibody, clone 2-23

    产品名称：Anti-Caspase 9 Antibody, clone 2-23
    产品型号：MAB4709
    Anti-Caspase 9 Antibody, clone 2-23 is an antibody against Caspase 9 for use in IP, WB, IH(P).

    merck millipore,默克密理博,MAB4709,Anti-Caspase 9 Antibody, clone 2-23

  • 产品介绍
  • merck millipore,默克密理博,MAB4709,Anti-Caspase 9 Antibody, clone 2-23

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB4709
    Replaces 04-443
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Caspase 9 Antibody, clone 2-23
    Alternate Names
    • Apaf-3
    • ICE-LAP6
    • Mch-6
    产品信息
    格式 Purified
    演示 Purified immunoglobulin by protein A. Liquid in PBS, pH 7.6, with 0.1% sodium azide.
    应用
    应用 Anti-Caspase 9 Antibody, clone 2-23 is an antibody against Caspase 9 for use in IP, WB, IH(P).
    主要应用
    • Western Blotting
    应用说明 Western blot: 1:1000 Immunohistochemistry (frozen and paraffin): 1:500 - 1:1000

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Recombinant human caspase-9 prodomain
    克隆 2-23
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Recognizes 46-48 kDa full-length procaspase-9, human recombinant caspase-9 and procaspase-9 from human cell lysates. Highly specific to caspase-9 and shows no cross-reaction with other caspase family members. Activation of procaspase-9 by Apaf-1 in the cytochrome c pathway requires proteolytic cleavage to generate active caspase-9. Once activated, capsase-9 initiates a caspase cascade involving the downstream executioner caspases 3, 6 and 7.
    同种型 IgG1
    品种反应性 MouseHuman
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_032996.1
    • NM_001229.2
    Entrez基因汇总 This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade. Alternative splicing results in two transcript variants which encode different isoforms.
    基因符号
    • Caspase-9 subunit p10].
    • CASP9
    • CASP-9
    • ICE-LAP6
    • MCH6
    • APAF3
    • CASPASE-9c
    • OTTHUMP00000044594
    • APAF-3
    • EC 3.4.22.62 [Contains: Caspase-9 subunit p35
    非反应性品种
    • Rat
    UniProt编号
    • P55211
    UniProt汇总 FUNCTION: SwissProt: P55211 # Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
    SIZE: 416 amino acids; 46281 Da
    SUBUNIT: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 35 kDa (p35) and a 10 kDa (p10) subunit. Caspase-9 and APAF1 bind to each other via their respective NH2-terminal CED-3 homologous domains in the presence of cytochrome C and ATP. Interacts with the inhibitors BIRC2, BIRC4, BIRC5 and BIRC7.
    TISSUE SPECIFICITY: Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues.
    PTM: Cleavages at Asp-315 by granzyme B and at Asp-330 by caspase- 3 generate the two active subunits. Caspase-8 and -10 can also be involved in these processing events.
    SIMILARITY: SwissProt: P55211 ## Belongs to the peptidase C14 family. & Contains 1 CARD domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB4709,Anti-Caspase 9 Antibody, clone 2-23

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