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品种反应性 主要应用 宿主 格式 抗体类型 M FC M Purified Monoclonal Antibody 描述 产品目录编号 MABF73 描述 Anti-Tim3 Antibody, clone 5D12 Alternate Names - TIM-3
- Hepatitis A virus cellular receptor 2 homolog
- T-cell immunoglobulin and mucin domain-containing protein 3
- T-cell membrane protein 3
- TIMD-3
背景信息 As a member of the T cell immunoglobulin and mucin domain (TIM) family, Tim-3 is reported to promote or terminate Th1 immunity and is thought to influence a range of inflammatory conditions. It is constitutively expressed in a subset of murine IFNgamma-secreting Th1 cells, but not Th2 cells, in both human and mice. Additionally, Tim-3 is expressed dendritic cells, and by a subset of CD4+ cells where its levels of expression increase upon anti-CD3/28 stimulation. This molecule is also be highly expressed in in vitro polarized Th1 cells, and at lower levels in Th17 cells. Tim-3 is known to synergize with Toll-like receptors (TLRs) and is thought to regulate Th1 and Th17 cytokine secretion. 产品信息 格式 Purified 控制 - RAW264.7 cells
演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Tim3 Antibody, clone 5D12 is an antibody against Tim3 for use in FC. 主要应用 - Flow Cytometry
生物信息 免疫原品种 Recombinant protein corresponding to full length mouse Tim3. 克隆 5D12 宿主 Mouse 同种型 IgG1κ 品种反应性 Mouse Species Reactivity Note Demonstrated to react with Mouse. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_599011
Entrez基因汇总 CD4 (MIM 186940)-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. 基因符号 - Timd3
- Havcr2
- Tim3
纯化方法 Protein G Purified UniProt编号 - Q8VIM0
UniProt汇总 FUNCTION: Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.产品使用声明 质量保证 Evaluated by Flow Cytometry in RAW264.7 cells.
Flow Cytometry Analysis: A 1:50 dilution of this antibody detected Tim3 in RAW264.7 cells.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µL
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