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品种反应性 主要应用 宿主 格式 抗体类型 Rb, H, M WB Rb Serum Polyclonal Antibody 描述 产品目录编号 07-728 品牌系列 Upstate
商名 - Upstate
描述 Anti-HRI Antibody 产品信息 格式 Serum 应用 应用 Detect HRI using this Anti-HRI Antibody validated for use in IP & WB. 主要应用 - Western Blotting
生物信息 免疫原品种 6His-tagged fusion protein corres-ponding to residues 1-138 of mouse heme-regulated inhibitor (HRI) 宿主 Rabbit 特异性 HRI 同种型 IgG 品种反应性 RabbitHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_014413.2
Entrez基因汇总 The HRI gene is localized to 7p22 where its 3' end slightly overlaps the 3' end of the gene JTV1. The two genes are transcribed from opposite strands. Studies in rat and rabbit suggest that the HRI gene product phosphorylates the alpha subunit of eukaryotic initiation factor 2. Its kinase activity is induced by low levels of heme and inhibited by the presence of heme. 基因符号 - HRI
- EIF2AK1
- KIAA1369
- HCR
纯化方法 Serum UniProt编号 - Q9BQI3
UniProt汇总 FUNCTION: SwissProt: Q9BQI3 # Mediates down-regulation of protein synthesis in response to various stress conditions by the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser-51'. Protein synthesis is inhibited at the level of initiation (By similarity).
SIZE: 630 amino acids; 71106 Da
SUBUNIT: Synthesized in an inactive form that binds to the N- terminal domain of CDC37. Has to be associated with a multiprotein complex containing Hsp90, CDC37 and PPP5C for maturation and activation by autophosphorylation. The phosphatase PPP5C modulates this activation. Homodimer; non-covalently bound in the absence of hemin. Converted to an inactive disulfide linked homodimer in the presence of hemin (By similarity).
TISSUE SPECIFICITY: Detected in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, kidney, spleen, muscle and stomach.
PTM: Activated by autophosphorylation; phosphorylated predominantly on serine and threonine residues, but also on tyrosine residues (By similarity).
SIMILARITY: SwissProt: Q9BQI3 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. & Contains 2 HRM (heme regulatory motif) repeats. & Contains 1 protein kinase domain.
MISCELLANEOUS: Can bind 2 molecules of heme per polypeptide chain (By similarity).产品使用声明 质量保证 Routinely evaluated by immunoblot on lysates from mouse reticulocytes. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C from date of shipment 包装信息 数量 100 µL
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